Distinct proteomic, transcriptomic and epigenetic stress-responses in dorsal and ventral hippocampus
Acutely stressful experiences can trigger neuropsychiatric disorders and impair cognitive processes, by altering hippocampal function. Although the intrinsic organization of the hippocampus is highly conserved throughout its long dorsal-ventral axis, the dorsal (anterior) hippocampus mediates spatial navigation and memory formation, whereas the ventral (posterior) hippocampus is involved in emotion regulation. To understand the molecular consequences of stress, detailed genome-wide screens are necessary and need to distinguish between dorsal and ventral hippocampus.
Source: Biological Psychiatry - Category: Psychiatry Authors: Amalia Floriou-Servou, Lukas von Ziegler, Luzia Stalder, Oliver Sturman, Mattia Privitera, Anahita Rassi, Alessio Cremonesi, Beat Th öny, Johannes Bohacek Tags: Archival Report Source Type: research