Distinct proteomic, transcriptomic and epigenetic stress-responses in dorsal and ventral hippocampus

Acutely stressful experiences can trigger neuropsychiatric disorders and impair cognitive processes, by altering hippocampal function. Although the intrinsic organization of the hippocampus is highly conserved throughout its long dorsal-ventral axis, the dorsal (anterior) hippocampus mediates spatial navigation and memory formation, whereas the ventral (posterior) hippocampus is involved in emotion regulation. To understand the molecular consequences of stress, detailed genome-wide screens are necessary and need to distinguish between dorsal and ventral hippocampus.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research