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Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil

This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals and symptoms: headache, myalgia or arthralgia, conjunctivitis, pruritus, retro-orbital pain and prostration were recruited as suspicion of arboviral infection. Moreover, patients with acute onset of generalized macular or papular rash, pruritus and conjuctival hyperemia were considered as zika suspected cases according to the Brazilian Ministry of Healthy Protocol8. Patients with acute fever presenting two or more of the following signs or symptoms: nausea, vomiting, myalgia, arthralgia, headache, retro orbital pain, petechiae, positive tourniquet test, thrombocytopenia and leucopenia were considered as dengue suspected cases according to the Brazilian Ministry of Health9. An infectious disease physician collected data on demographic characteristics, symptoms and physical signs. Detailed clinical examination was registered immediately after admission and blo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Conclusions: We did not find any impact of brain atrophy on the risk of END and the outcome at 3 months in severe ischemic strokes after IV thrombolysis.Eur Neurol 2018;79:240 –246
Source: European Neurology - Category: Neurology Source Type: research
An inspection report released Thursday by the US Food and Drug Administration indicates that the North Carolina farm linked to a multistate outbreak of Salmonella from contaminated eggs had an ongoing rodent infestation, unsanitary conditions and poor employee practices.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
CONCLUSION: The finding of a family risk of developing plurimetabolic syndrome and a diagnosis of rheumatic heart disease indicates that patients with oral clefts may be more prone to developing acquired heart disease. Thus, our findings highlight the importance of anamnesis and methodological triangulation (clinical-electrocardiographic-echocardiographic) in the investigation of patients with oral clefts and emphasize that cardiological follow-up to evaluate acquired and/or rhythm heart diseases is necessary. This strategy permits comorbidity prevention and individualized planned treatment.
Source: Clinics - Category: General Medicine Source Type: research
Sexual harassment and assault investigation at UNAIDS draws attention to an endemic problem. Critics say the UN's internal system is flawed and call for external oversight. John Zarocostas reports.
Source: LANCET - Category: General Medicine Authors: Tags: Special Report Source Type: research
The American physician and writer, Danielle Ofri, tells the story of a near fatal mistake that she made at the beginning of the second year of her residency. A patient was brought to the emergency room in a diabetic coma, and although her initial management was fine, Ofri then made an error and “proceeded to nearly kill…[the] patient”. Recognising her predicament, she called for senior assistance. When an explanation was demanded of her performance, Ofri's words dried up. Humiliation set in as she was questioned in front of her intern: “I could almost feel myself dying away on the spot.
Source: LANCET - Category: General Medicine Authors: Tags: Perspectives Source Type: research
China's childhood hepatitis B virus (HBV) vaccination programme is a great public health success, resulting in a prevalence of HBsAg of only 1% in children under 5 years. However, the burden of HBV infection in China is still the highest in the world, with one third of the world's 240 million people with chronic HBV living in China.1 Nevertheless, most people with HBV infection in China are unaware that they carry the disease, making HBV infection a truly silent epidemic.2
Source: LANCET - Category: General Medicine Authors: Tags: Correspondence Source Type: research
The report by Gill Livingston and colleagues (Dec 16, 2017 p 2673)1 is a valuable collation of a large body of medical research evidence that aims to combat the dementia epidemic, the greatest global challenge for health and social care in the 21st century. One of the key messages of the Commission is the need to be ambitious in terms of prevention. Using population attributable fractions (PAF), the authors estimate that as much as 35% of dementia cases could be prevented by targeting nine modifiable risk factors.
Source: LANCET - Category: General Medicine Authors: Tags: Correspondence Source Type: research
Nguyen T-N, von Seidlein L, Nguyen T-V, et al. The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study. Lancet Infect Dis 2018; 18: 565 –72—In this Article, the lowest parasite densities shown in figure 3 were found to be below the lower limit of accurate quantification of the PCR method used in the study (22 parasites per mL). The analysis was therefore redone after excluding these low parasite densities.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Tags: Corrections Source Type: research
100 years have passed since the first well documented influenza pandemic of the 20th century. Today, the majority of the influenza virus burden is known to be caused by two main types of influenza virus —type A and type B. Human influenza A viruses generally stem from birds and swine, whereas influenza B viruses do not have a known animal reservoir, and simply circulate among human beings. Although pandemics occur unexpectedly, these outbreaks are theorised to emerge after a lengthy reassortment process, and not from the direct introduction of an avian virus into human beings.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
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