Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil

This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals and symptoms: headache, myalgia or arthralgia, conjunctivitis, pruritus, retro-orbital pain and prostration were recruited as suspicion of arboviral infection. Moreover, patients with acute onset of generalized macular or papular rash, pruritus and conjuctival hyperemia were considered as zika suspected cases according to the Brazilian Ministry of Healthy Protocol8. Patients with acute fever presenting two or more of the following signs or symptoms: nausea, vomiting, myalgia, arthralgia, headache, retro orbital pain, petechiae, positive tourniquet test, thrombocytopenia and leucopenia were considered as dengue suspected cases according to the Brazilian Ministry of Health9. An infectious disease physician collected data on demographic characteristics, symptoms and physical signs. Detailed clinical examination was registered immediately after admission and blo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Authors: Scheffer-Rath ME, Boot AM Abstract Vitamin D is important for skeletal growth, bone mineralization and dental health. Vitamin D deficiency is reported in many countries, may have several causes and can cause rickets in children. A guideline with recommendations of vitamin D supplementation to prevent nutritional rickets was published recently. The vitamin D receptor is present in many cells of the body including cells of the immune system. Many studies have been published on associations between vitamin D deficiency and extra skeletal effects, mainly without proof of causality in intervention studies. This...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Henry RK Abstract Glucose dysregulation (GD), a feature of growth hormone excess, in the setting of acromegaly is well known by clinicians. However, less well known is that GD may be a feature of growth hormone deficiency. The fact that either ends of the spectrum of growth hormone (excess or deficiency) can be associated with diabetes mellitus is unique and clinicians should especially recognize that impaired glucose tolerance and even diabetes mellitus may develop in individuals predisposed to having growth hormone deficiency. PMID: 32780951 [PubMed - in process]
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Blumenfeld O, Hampe CS, Shulman L, Chen R, Laron Z Abstract Recent epidemiological surveys performed in Australia, USA and Israel demonstrate that Rotavirus vaccination correlates with an attenuated prevalence and/or incidence of early childhood diabetes (T1D). Other studies failed to confirm the above. PMID: 32780950 [PubMed - in process]
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Publication date: 5 December 2020Source: Journal of Ethnopharmacology, Volume 263Author(s): Xiaoning Chen, Ravindran Kalathil Veena, Haridas Ramya, Kainoor Krishnankutty Janardhanan, Varughese George
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 12 August 2020Source: Current Therapeutic ResearchAuthor(s): D.D. Gladman, A.M. Orbai, J. Gomez-Reino, S. Chang-Douglass, E. Leoncini, H.E. Burton, K.S. Kanik, A.B. Romero, J.C. Cappelleri, M-A. Hsu
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Publication date: October 2020Source: Biomedicine &Pharmacotherapy, Volume 130Author(s): Yafeng Wang, Delong Duo, Yingjun Yan, Rongyue He, Xinan Wu
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
When I started my clinical training in dermatology in 1981 and got involved in basic research in 1984, in those days for young German-speaking dermatology researchers, there was one important scientific meeting, the meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF, Association of Dermatological Research). Presenting an abstract at this meeting was a must, and having been selected for oral presentation was an extraordinary achievement. There was another extremely important forum, the meeting of the Society of Investigative Dermatology (SID).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Scientific Articles Source Type: research
Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Clinical Article Source Type: research
Conclusions: There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients. PMID: 32774367 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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