Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil

This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals and symptoms: headache, myalgia or arthralgia, conjunctivitis, pruritus, retro-orbital pain and prostration were recruited as suspicion of arboviral infection. Moreover, patients with acute onset of generalized macular or papular rash, pruritus and conjuctival hyperemia were considered as zika suspected cases according to the Brazilian Ministry of Healthy Protocol8. Patients with acute fever presenting two or more of the following signs or symptoms: nausea, vomiting, myalgia, arthralgia, headache, retro orbital pain, petechiae, positive tourniquet test, thrombocytopenia and leucopenia were considered as dengue suspected cases according to the Brazilian Ministry of Health9. An infectious disease physician collected data on demographic characteristics, symptoms and physical signs. Detailed clinical examination was registered immediately after admission and blo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Publication date: Available online 12 December 2018Source: Journal of the American College of RadiologyAuthor(s): Tami J. France, Ronald Menaker, Kent R. ThielenAbstractSuccessful physician and administrator leader partnerships are a key differentiator in today’s volatile, unpredictable, ever-changing health care landscape. Whether they are leading a division, a department, or an organization, intentional and mindful physician-administrator partnerships affect success from the micro individual level to the macro organizational level. Mayo Clinic's physician and administrative leaders are leveraging a long-held t...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Publication date: Available online 12 December 2018Source: Journal of the American College of RadiologyAuthor(s): Felix M. Gonzalez, J. Matthew Kerchberger, Douglas D. Robertson, Yara Younan, Adam Singer, Walter A. Carpenter, Richard Duszak, James R. Roberson, Monica B. UmpierrezAbstractPurposeTo evaluate the appropriateness of MRI ordering practices and their effect on clinical management for nontraumatic knee pain at the primary care clinics of a large public urban hospital.Materials and MethodsIn all, 196 consecutive MRIs for nontraumatic knee pain ordered from primary care clinics in a large public urban hospital over ...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
CONCLUSIONS: This study provides further evidence on the short-term variability of SI in very short time frames implying the need of assessing SI repeatedly in clinical and research settings. The associations between interpersonal variables and passive and active SI were only partial in line with assumptions of the Interpersonal Theory of Suicide. Overall, the effects were small warranting further investigation. PMID: 30530103 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
A 66-year-old ex-smoker presented with metastatic renal cell cancer with lytic lesions in the left femur, T8, and a 1.5-cm lesion in the right lung. A biopsy from the femur confirmed clear cell renal cell cancer; the lung lesion could not be biopsied safely. The patient underwent a radical nephrectomy (pathologically staged as pT3a). He commenced sunitinib, which was stopped owing to severe hypertension, followed by everolimus, stopped after 8 cycles owing to muscle cramping. Repeat imaging demonstrated resolution of the lung nodule but progression in the left femur, T8, and new disease in the anterior right 10th rib and left humerus.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Authors: Wu Y, Jia K, Wu H, Sang A, Wang L, Shi L, Jiang K, Dong J Abstract Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA‑miRNA‑mRNA interactions in DR are poorly understood. In the present study, we aimed to compute a global triple network of competitive endogenous RNAs (ceRNAs) in order to pinpoint essential molecules. We found that there were 802 ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Intranasal instillation of miR‑410 targeting IL‑4/IL‑13 attenuates airway inflammation in OVA‑induced asthmatic mice. Mol Med Rep. 2018 Nov 28;: Authors: Jin R, Hu S, Liu X, Guan R, Lu L, Lin R Abstract Asthma is a common chronic inflammatory respiratory disease characterised by airway inflammation and hyperresponsiveness. The present study was designed to clarify the effect of intranasal miR‑410 administration in an ovalbumin (OVA)‑induced murine model of asthma. It was found that miR‑410 expression was significantly decreased in the lungs of OVA‑induced asthmatic mice (P
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function. Mol Med Rep. 2018 Nov 29;: Authors: Li J, Li N, Yan S, Lu Y, Miao X, Gu Z, Shao Y Abstract Mitochondrial homeostasis is a highly regulated process that serves a critical role in the maintenance of renal structure and function. The growing interest in the field of mitochondrial homeostasis promises to provide more information regarding the mechanisms involved in diabetic renal fibrosis, and aid in the development of novel strategies to combat the disease. In the ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Upregulated IGF‑1 in the lungs of asthmatic mice originates from alveolar macrophages. Mol Med Rep. 2018 Dec 05;: Authors: He J, Mu M, Wang H, Ma H, Tang X, Fang Q, Guo S, Song C Abstract Asthma is characterized by inflammation and remodeling of the airways. Insulin‑like growth factor-1 (IGF‑1) serves an important role in the repair of lung tissue injury and airway remodeling by elevating collagen and elastin content, increasing the thickness of smooth muscle and promoting the proliferation of lung epithelial and interstitial cells, as well as fibroblasts; however, the content of IGF‑1 and...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
We thank the authors for the comments related to this article. We appreciate their comments and suggestions and agree that these studies can be challenging but can also move patient care forward. Obtaining accurate pain scores can be highly subjective and relies on patients reporting pain at a single point in time and a nurse recording the pain score accurately.7 Although pain is subjective, our ability to enter and access the data is much less subjective. In our institution, we have a highly integrated electronic medical records system through EPIC Enterprises (Verona, WI, USA).
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
TYPE 2 DIABETES symptoms may not be obvious for many years and can be mistaken for less serious conditions. But recognising all the warning signs is very important because left untreated, life-threatening complications can occur. One sign to be wary of can be evident in your urine.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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