Study suggests expanded range for emerging tick-borne disease
New research led by the Yale School of Public Health suggests that Borrelia miyamotoi ’s geographic range is bicoastal, far larger than previously believed.
Borrelia burgdorferi sensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system binding to purine nucleosides. Nucleosides are essential for bacterial survival in the host organism, and these studies suggest a key role for Bmp...
This study illustrates potential threat to domestic animals and humans from tick-borne pathogens. PMID: 32145725 [PubMed - as supplied by publisher]
V. Muigg et al.
Conclusions: This study found a high incidence of Lyme disease in Lithuania. We elucidated the baseline characteristics regarding the infected Lithuanian population which may ease medical clinicians' work on new Lyme diagnoses. PMID: 32151097 [PubMed - in process]
Publication date: Available online 26 February 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Seunghee Lee, Hyunkyoung Lee, Jung-Won Park, Soon-Seek Yoon, Hyun-Ji Seo, Jinhyeong Noh, Mi-Sun Yoo, Keun-Ho Kim, Yeojin Park, Yun Sang Cho, Byung Jae So
Publication date: Available online 24 February 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Cecilie Lerche Nordberg, Jacob Bodilsen, Fredrikke Christie Knudtzen, Merete Storgaard, Christian Brandt, Lothar Wiese, Birgitte Rønde Hansen, Åse Bengård Andersen, Henrik Nielsen, Anne-Mette Lebech, DASGIB study groupAbstractThe goal of this paper is to characterize the clinical presentation, serological results, current antibiotic treatment practice, including compliance with current European guidelines, and outcome in adults with Lyme neuroborreliosis (LNB) diagnosed at department of infectious diseases ...
The incidence of tick-borne infections in the United States has risen significantly in the past decade. Ticks can transmit a variety of pathogens, including bacteria, protozoa, and viruses, that can cause serious illnesses. Therefore, the use of rapid, sensitive, and specific multiplex tests is important to identify the pathogen(s) in the acute phase and determine appropriate treatment to minimize the severity of the disease. The purpose of this study was to evaluate ChromaCode’s research use only (RUO) nine-target high-definition PCR (HDPCR) tick-borne pathogen (TBP) panel using 379 retrospective, remnant whole-bloo...
Conclusions: The interleukin-6/interleukin-10 ratio can be used as a rapid diagnostic cue upon suspected tick-borne infection, enabling fast and correct treatment. Also, in serology-negative results, such information may strengthen a clinical suspicion.
This study highlights the diversity of bacterial genera harboured within wildlife ticks, which may prove to be of medical and/or veterinary importance in the future.Graphical abstract
CONCLUSION: This diagnosis should be evocated in patients having fever after a trip in infested area, as malaria, both infections can be associated. PMID: 32014353 [PubMed - as supplied by publisher]