Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: a randomized controlled trial

Vegetarians and vegans are more vulnerable to vitamin B12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression. An easy and simple method of supplementation consists of taking one weekly dosage of 2000 μg. However, single large oral doses of vitamin B12 are poorly absorbed. The present research evaluates the ability of two different sublingual dosages of vitamin B12 (350 μg/week vs. 2000 μg/week) in improving cyanocobalamin (vitamin B12) nutritional status in vegans and vegetarians with a margi nal deficiency.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Randomized Control Trials Source Type: research

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ConclusionsNutrition screening tools with good/strong or fair evidence and moderate validity included the Screening Tool for the Assessment of Malnutrition in Pediatrics, Screening Tool for Risk on Nutritional Status and Growth, and Paediatric Yorkhill Malnutrition Score in the inpatient setting and Nutrition Risk Screening Tool for Children and Adolescents with Cystic Fibrosis in the specialty setting. No tools in the community setting met these criteria. While differences in validity and reliability measures among tool users were found, the significance of these findings is unclear. Limitations included few studies exami...
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
This study evaluated associations of serum matrix Gla protein (MGP), plasma vitamin K1, and plasma vitamin K2 with coronary artery calcium score (CACS) and cardiovascular disease (CVD) in maintenance hemodialysis (MHD) patients. Methods: Subjects comprised 112 MHD patients aged 30-60 years and 40 age-matched healthy subjects. Total MGP, vitamin K1, vitamin K2, and lipid profile were examined in all subjects; other clinical data, medication use, and CACS were assessed only in MHD patients. Determinants of MGP in all subjects were identified by regression analysis. Factors associated with CACS and CVD in MHD patients ...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Authors: Gawlinska K, Gawlinski D, Przegalinski E, Filip M Abstract A balanced maternal diet is necessary for the proper health and development of offspring. Recent clinical and preclinical studies have strongly indicated that maternal exposure to a high-fat diet (HFD) can have an irreversible impact on the structure and function of the offspring's brain and affect the immune system, which may predispose the offspring to brain disorders, including depression. The irisin/brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of menta...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
[Paternal depression in a "stay-at-home" father - case report]. Neuropsychopharmacol Hung. 2019 Sep;21(3):136-141 Authors: Hajnaczky L, Lazary J Abstract There is a growing body of data on paternal peripartum depression (perinatal depression in father; PND-F), however, it has traditionally been investigated only in women. Recently accumulating results confirmed the prominent role of the mental health of fathers in the psychosocial development of children and new trends showed up concerning the father's role in the family. In this case report we demonstrate the clinical aspect of a depressive ...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Authors: Zonda T, Paksi B, Bozsonyi K, Veres E Abstract In our study we have summarised the various fields of our suicide research made in the last 40 years. We have devided our whole publications into thematic chapters: cultural-history, regional differences, follow-up studies, prenvention, ecological researches, mostly sociology. Some of them had been firstly published in Hungarian or/and also in international literature. We repeatedly reiterate the importance of writing a Hungarian suicide prevention program. We agree with the opinion: "Suicide prevention is far more than a psychiatric business". P...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
[Cariprazine, a new type - dopamine Dā‚ƒ receptor preferring - partial agonist atypical antipsychotic for the treatment of schizophrenia and the primary negative symptoms]. Neuropsychopharmacol Hung. 2019 Sep;21(3):103-118 Authors: Laszlovszky I, Kiss B, Barabassy A, Kapas M, Nemeth G Abstract Dopamine Dā‚‚ receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of s...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Publication date: Available online 20 September 2019Source: Journal of Herbal MedicineAuthor(s): Ying Wang, Yu-Jie Liu, Feng-E Li, Zhi Guo, Jun Wang, Comorbid Depression and Coronary Heart Disease Research Group of Cangzhou Central HospitalAbstractDepression is one of the major risk factors for the development, progression and prognosis of coronary heart disease (CHD). Patients with depression and CHD have high mortality and morbidity. Conventional antidepressant therapies achieve limited success in CHD patients. The aim of the present study was to determine the efficacy of a formulation of Chinese herbal medicine called t...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
ConclusionThe findings of the randomized and sham-controlled trial will demonstrate that acupuncture therapy is effective and safe for patients with PPD through probablly regulating the gut microbiota dysfunction. These findings might have an important impact on the practice of acupuncture for patients with PPD.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Official advice from the drug regulator is a victory for The Mail on Sunday, after we revealed that many patients, including children, said that montelukast had deeply affected their behaviour.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Homocysteine (Hcy) is thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of the folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria are connected with occlusive artery disease, especially in the brain, the heart, and the...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
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