O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis

Hepatocellular carcinoma (HCC) is the sixth-most frequent and the second-most lethal cancer worldwide, with a rising incidence in developing and industrialized countries[1]. Until now, surgery has remained the most effective treatment with curative potential. Nevertheless, most patients are still diagnosed at an advanced/late stage when surgery is no longer applicable, and display symptoms of intrahepatic and extrahepatic metastasis[2]. Few effective treatment options exist for patients with advanced HCC, with a 5 year survival rate of around only 30% –40%[3].

Source: Journal of Hepatology - February 15, 2018 Category: Gastroenterology Authors: Fangfang Duan, Hao Wu, Dongwei Jia, Weicheng Wu, Shifang Ren, Lan Wang, Shushu Song, Xinying Guo, Fenglin Liu, Yuanyuan Ruan, Jianxin Gu Source Type: research