CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling

This study demonstrates increased susceptibility of CKO mice to ISO-induced acute and chronic cardiac injury due to, at least in part, elevated CaMKII activity. Deleting Crabp1 results in reduced baseline cardiac function and aggravated damage challenged with acute and persistent β-adrenergic stimulation. This is the first report of a physiological role of CRABP1 as an endogenous regulator of CaMKII, which protects the heart from ISO-induced damage.

Source: Journal of Endocrinology - February 15, 2018 Category: Endocrinology Authors: Park, S. W., Persaud, S. D., Ogokeh, S., Meyers, T. A., Townsend, D., Wei, L.-N. Tags: Research Source Type: research