Sevoflurane For Procedural Sedation In Critically Ill Patients: A Pharmacokinetic Comparative Study Between Burn And Non-Burn Patients

Conclusion We observed an increased volume of distribution, slower elimination rate, and altered metabolism of sevoflurane in burn patients compared to controls. Repeated use for procedural sedation in burn patients needs further evaluation. No renal toxicity was detected. Trial registry number ClinicalTrials.gov Identifier NCT02048683
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research