Inside One Couple ’s Experimental Treatment to Battle Alzheimer’s Disease

JoAnn Wooding is staring intently at the clear liquid dripping from a dark brown IV bag into her husband Peter’s arm. “Please be the drug, please be the drug,” she says. Married for more than 50 years, the Woodings are among the more than 5 million Americans who are facing Alzheimer’s disease, one of the most devastating diagnoses today. But instead of accepting the slow descent into memory loss, confusion and dementia, Peter–who has the disease–could be among the first to successfully stop that decline from happening. Peter, 77, is one of the 2,700 people around the world who are expected to volunteer to test what researchers believe could be the first drug to halt Alzheimer’s. Two-thirds of the volunteers will receive the drug, and one-third will get a placebo. They won’t know which one they received until they have participated for 18 months. While there are genes that contribute to a higher risk of Alzheimer’s, for most people, age is the biggest risk factor for the disease. The human brain is remarkably resilient, but only up to a point. With time, connections that normally call up a memory or help remind people where they are start to get weaker. The first symptoms might be as innocuous as forgetting where you left your phone or missing an appointment. In most cases, the first memories to slip away are more recent ones. Slowly, sophisticated tasks such as organizing a trip, paying bills or driving to familiar places...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease healthytime Longevity Source Type: news

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Conclusions: Results from a head-to-head study showed that, compared with secukinumab, guselkumab had lower NNTs and CPRs for PASI 75, PASI 90, and PASI 100 responses. PMID: 32479140 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Perez BA, Slover J, Edusei E, Horan A, Anoushiravani A, Kamath AF, Nelson CL Abstract BACKGROUND: Total joint arthroplasty is one of the most common surgeries performed in the United States with total knee arthroplasty (TKA) being one of the most successful surgeries for restoring function and diminishing pain. Even with the demonstrated success of TKA and a higher prevalence of arthritis and arthritis related disability among minorities, racial and gender disparity remains a constant issue in providing care for the adult reconstruction patient. AIM: To assess the role of demographics and expectations ...
Source: World Journal of Orthopaedics - Category: Orthopaedics Tags: World J Orthop Source Type: research
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Authors: Barber MRW, Clarke AE Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. AREAS COVERED: This narrative review provides an overview of rec...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an as...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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