Why Pig Organs Could Be the Future of Transplants
Making human tissue in a lab has always been more sci-fi than sci-fact, but powerful genetic technologies may change that soon. For the most part, the only way to replace diseased or failing hearts, lungs, kidneys and livers is with donor organs. Even then, many people struggle to find a good biological match with a donor, and 8,000 die each year in the U.S. while waiting for an organ. In one promising solution to the shortage, researchers have been putting a new DNA editing tool called CRISPR through rigorous tests in organ regeneration. Last August, a group of scientists led by George Church, professor of genetics at Harvard Medical School, generated more than a dozen pigs that were bred without certain viruses that had made many of their organs unusable for human transplant. Pig genomes often contain genes for viruses that can cause infection and, if they spread to certain tissues, even cancer. Church used CRISPR to snip out these viral genes from the pig DNA. While there are other ways to edit DNA, CRISPR, developed in 2012, is by far the most precise set of molecular tools to cut, paste, copy and move genes around. In order to ensure that all the tissues in the pigs were free of the viruses, Church and his team used a cloning technique to create embryos from the edited cells. Of 37 pigs that were born, 15 survived, and none showed genetic signs of the viruses. Church anticipates that pig-to-human organ transplant clinical trials could happen in as little as two years, w...
The imaging process provides the most time-efficient sequence with the highest lesion detection rate and conspicuity.
The same smartphone technology that can recognize a user's face and voice can now identify breast cancer tumors, a recent study said.
The American Cancer Society (ACS) National Lung Cancer Roundtable has launched...Read more on AuntMinnie.comRelated Reading: USPSTF opens review of CT lung screening guidance Kazerooni to chair ACS Lung Cancer Roundtable
Today's open access paper is, I think, chiefly interesting for the later section in which the authors ponder future directions for the treatment of aging via means of destroying or manipulating the activity of senescent cells. The accumulation of senescent cells is one of the root causes of aging. The creation of senescent cells happens constantly in the undamaged and fully functional tissues of young people, a tiny fraction of these senescent cells manage to evade destruction and linger to cause issues, and given enough time that fraction will grow large enough to kill you. Cellular senescence isn't the only harmful cause...
Abstract Prostate cancer, bladder cancer, and kidney cancer represent the 3 most common urologic malignancies, and form a heterogenous group of disease processes, with a wide range of pathologic features. As a urologist, a strong understanding of the pathologic features of urologic malignancies is essential to prognosticate and counsel patients and to determine the most effective course of treatment. This review discusses the pathologic features of prostate, bladder, and kidney cancer, and examines how detailed pathologic reporting is critical to today's practicing urologist. PMID: 30447847 [PubMed - in process]
This article discusses treatment paradigms for the most common urologic malignancies, followed by the evidence base to support the relationship between pathologic assessment and decision making by the medical oncologist. PMID: 30447846 [PubMed - in process]
This article reflects the aspects that are most influential on daily practice. A brief summary of 3 ancillary commercially available genomic tests is also provided. PMID: 30447840 [PubMed - in process]
Abstract Large-gland proliferations of the prostate have gained considerable attention in the past decade. The differential diagnosis is quite broad but can be refined using histologic criteria and, sometimes, immunostains. Pathologists have come to realize that cribriform and intraductal as well as ductal carcinomas are particularly aggressive patterns, and should name them in diagnostic reporting when present. PMID: 30447836 [PubMed - in process]
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