Herbal products for common auto-inflammatory disorders - Novel approaches.

Herbal products for common auto-inflammatory disorders - Novel approaches. Comb Chem High Throughput Screen. 2018 Feb 12;: Authors: Mahomoodally F, Suroowan S Abstract Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse. It was found that Indeed, herbal products can act on multiple targets involved in the pathogenesis of CAIDs. Curcumin, quercetin, naringenin, and hesperentin can nullify the damaging effects of reactive oxygen species (ROS). Periplocoside A, oroxylin A, and celastrol can redress the imbalance between T helper 17 and T regulatory cells and suppress inflammation. Moreover, berberine and salvianolic acid B have demonstrated action like conventional non-steroidal anti-inflammatory drugs and inhibit the cyclooxygenase-2 enzymes. Mentha spica ta oil causes analgesia and decreases pain. , Boswellia serrata Roxb. ex C...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research