Perioperative Inpatient Use of Selective Serotonin Reuptake Inhibitors Is Associated With a Reduced Risk of THA and TKA Revision.

CONCLUSIONS: The presence of a depression diagnosis confers an increased risk of revision and PJI among patients undergoing THA and TKA, yet the risk is lower within the subset of patients who received SSRIs during the perioperative period. Future longitudinal studies with detailed antidepressant medication histories are warranted to better understand the potential biologic effects of SSRI on the risk of revision in patients undergoing THA and TKA.
LEVEL OF EVIDENCE: Level III, therapeutic study.
PMID: 29432263 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - February 8, 2018 Category: Orthopaedics Authors: Yao JJ, Maradit Kremers H, Kremers WK, Lewallen DG, Berry DJ Tags: Clin Orthop Relat Res Source Type: research