G-protein coupled receptor auto-antibodies in thromboangiitis obliterans (Buerger’s disease) and their removal by immunoadsorption.

CONCLUSIONS: AgAAB directed against GPCR were identified in TAO patients with a clustering of agAAB directed against α-1-adrenergic receptor loop1 and ETA-receptor loop1. AgAA were eliminated by IA in the majority of cases. We suggest that these agAA play an important role in the pathogenesis of TAO and that their elimination might be responsible for the positive therapeutic effects reported in patients treated with IA.
PMID: 25147011 [PubMed - in process]

Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - August 31, 2014 Category: Surgery Authors: Klein-Weigel PF, Bimmler M, Hempel P, Schöpp S, Dreusicke S, Valerius J, Bohlen A, Boehnlein JM, Bestler D, Funk S, Elitok S Tags: Vasa Source Type: research