TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

TGFβ attenuates tumour response to PD-L1 blockade by contributing to
exclusion of T cellsTGFβ attenuates tumour response to PD-L1 blockade by contributing to
exclusion of T cells, Published online: 14 February 2018; doi:10.1038/nature25501In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

Source: Nature AOP - February 14, 2018 Category: Research Authors: Sanjeev Mariathasan Shannon J. Turley Dorothee Nickles Alessandra Castiglioni Kobe Yuen Yulei Wang Edward E. Kadel III Hartmut Koeppen Jillian L. Astarita Rafael Cubas Suchit Jhunjhunwala Romain Banchereau Yagai Yang Yinghui Guan Cecile Chalouni James Zia Source Type: research