Factors Associated with Malignancy in Hysteroscopically Resected Endometrial Polyps: a Systematic Review and Meta-Analysis

The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Independent investigators selected the studies and extracted the data. A meta-analysis was performed using a random-effects model and meta-regression. We identified 37 studies (21,057 patients) of endometrial polyps. The prevalence of pre-malignant and malignant lesions was 3.4% (95% confidence interval (CI):2.8-4.1, I2: 80.5%). Abnormal uterine bleeding (prevalence ratio (PR):1.47; 95% CI:1.27-1.69; I2:82.4%), menopausal status (PR:1.67; 95% CI:1.48-1.89; I2:78.4%), age >60 years (PR:2.41; 95% CI:1.84-3.16; I2:81.5%), diabetes mellitus (PR:1.76; 95% CI:1.43-2.16; I2:0.0%), systemic arterial hypertension (PR:1.50; 95% CI:1.20-1.88; I2:75.9%), obesity (PR:1.41; 95% CI:1.13-1.76; I2:41.2%) and tamoxifen use (PR:1.53; 95% CI:1.06-2.21; I2:0.0%) were associated with endometrial polyp malignancy. However, breast cancer (PR:0.83; 95% CI:0.44-1.57; I2:0.0%), hormonal therapy (PR:...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
In this study, we aimed to estimate the frequency of premalignant and malignant lesions in endometrial polyps, and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of premalignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Independent investigators ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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