Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2.

We report a significant elevation in global 5-mC levels of about 2-7% on average for sALS (p
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research

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Anjali Chouksey, Sanjay PandeyAnnals of Indian Academy of Neurology 2020 23(2):153-154
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Conclusion: Clinical features in our study showed differences from previous studies from the Indian subcontinent. We had more cognitive-onset patients. However, behavioral onset was lower in our study. Motor, behavioral and cognitive onset groups of HD were comparable regarding demographics, family history, CAG repeat lengths and major clinical features at the time of evaluation.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Discussion: This review suggests that levodopa has the potential to improve chorea in BTL syndrome while its use in chorea due to other disorders requires further study. BTL syndrome due to NKX2-1 mutation responded to levodopa while we did not find any case of chorea due to ADCY-5 mutation responding to levodopa.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
ConclusionsDysfunctions of the oculomotor and abducens nerves recovered within 6  months postoperatively. Tumor extension into the suprasellar region/sphenoid sinus was the only risk factor for oculomotor nerve paralysis. Eye/eyelid movements were more sensitive than the pupillary light reflex in reflecting nerve dysfunctions. Intraoperative utilization of the infratrigeminal i nterspace was the only risk factor for abducens nerve paralysis.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Marian L. Tupy andChelsea FollettThe current frontrunner among the contenders vying to become the Democratic Party ’s presidential candidate, Senator Bernie Sanders (D‑VT), sang Cuba’s praises in a recent60 Minutesinterview on CBS. Senator Sanders applauded Cuba ’s education and healthcare system. Potential Sanders supporters should know that Cuba’s literacy rate and healthcare system are nothing to lionize.First, consider literacy. According to Sanders, “When Fidel Castro came into office, you know what he did? He had a massive literacy program. Is that a bad thing? ” S...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Spastic paraplegia type 7 (SPG7), which represents one of the most common forms of autosomal recessive spastic paraplegia (MIM#607259), often manifests with a complicated phenotype, characterized by progressive spastic ataxia with evidence of cerebellar atrophy on brain MRI. Recent studies have documented the presence of peculiar dentate nucleus hyperintensities on T2-weighted images and frontal executive dysfunction in neuropsychological tests in SPG7 patients. Therefore, we decided to assess whether any particular MRI pattern might be specifically associated with SPG7 mutations and possibly correlated with patients' cogn...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Identification of repeat-associated non-AUG (RAN) translation in trinucleotide (CAG) repeat diseases has led to the emerging concept that CAG repeat diseases are caused by nonpolyglutamine products. Nonetheless, the in vivo contribution of RAN translation to the pathogenesis of CAG repeat diseases remains elusive. Via CRISPR/Cas9-mediated genome editing, we established knock-in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
This study evaluates the effect of IMT on cardiorespiratory coupling in amateur cyclists. Thirty male young healthy cyclists underwent a sham IMT of very low intensity (SHAM, n = 9), an IMT of moderate intensity at 60% of the maximal inspiratory pressure (MIP60, n = 10) and an IMT of high intensity at the critical inspiratory pressure (CIP, n = 11). Electrocardiogram, non-invasive arterial pressure, and thoracic respiratory movement (RM) were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during active standing (STAND). The beat-to-beat series of heart period (HP) and systolic arteria...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia, hypertension, tachycardia, tachypnea, diaphoresis, dystonia (hypertonia or spasticity), and even motor features such as extensor/flexion posturing. Despite the pathophysiology of PSH not being completely understood, most researchers gradually agree that PSH is driven by the loss of the inhibition of excitation in the sympathetic nervous system without parasympathetic involvement. Recently, advances in the clinical and diagnostic features of PSH in TBI patients have reached a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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