Enteral administration of TKIs: report of a response to ceritinib in an ALK-positive NSCLC patient and literature review.

Enteral administration of TKIs: report of a response to ceritinib in an ALK-positive NSCLC patient and literature review. Curr Drug Targets. 2018 Feb 12;: Authors: Facchinetti F, Bordi P, Bini P, Bidin L, Camisa R, Tiseo M Abstract INTRODUCTION: Several reports attest the feasibility and the favorable outcomes of kinase inhibitors administration through feeding tubes or percutaneous endoscopic gastrostomies (PEG), mainly in non-small cell lung cancer (NSCLC) patients exposed to first-generation compounds. Here we present the case of an ALK-positive NSCLC patient who achieved cerebral and extra-cranial disease response with ceritinib (a novel ALK inhibitor) administered through a nasogastric tube (NGT). We moreover provide a review gathering clinical successes obtained with targeted agents intake through NGT or PEG. CASE PRESENTATION: A 53-year-old never-smoker woman was diagnosed with ALK-rearranged stage IV lung adenocarcinoma. After a brilliant response to crizotinib and several lines of systemic therapy, NGT positioning intended for ceritinib administration was required, given the development of a pleuro-esophageal fistula. Enteral drug administration allowed a significant reduction of hepatic and cerebral disease localizations. Literature review and discussion: The majority of kinase inhibitors administration through NGT or PEG accounts for EGFR-mutated (seven) or ALK-positive (seven, including our report) NSCLC patients. Five additional cases c...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research

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In conclusion, our study demonstrates that SHMT2 contributes to tumorigenesis in FP RMS and that SHMT2 amplification predicts differential response to drugs targeting this metabolic pathway.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Analyst, 2021, Accepted Manuscript DOI: 10.1039/D1AN01071A, PaperHuiying Xu, Lu Zheng, Yu Zhou, Bang-Ce Ye Tumor-related exosomes, which are heterogeneous membrane-enclosed nanovesicles shed from cancer cells, have been widely recognized as potential noninvasive biomarkers for early cancer diagnosis. Herein, an artificial enzyme cascade amplification strategy... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
In NIEHS-sponsored talk, Yu-Ying He, Ph.D., suggested RNA modifications are crucial players in regulating gene-environment interactions. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
Background: In a previous exploratory study, we reported lower concentrations of the ovarian reserve biomarker anti-Müllerian hormone (AMH) in adulthood with prenatal farm exposure. We now examine this association as well as childhood farm exposure using enrollment data from the Sister Study, a large US cohort of women. Methods: We collected prenatal and childhood farm exposure data by questionnaire and telephone interview. However, serum AMH data were available only for a nested subset: premenopausal women ages 35–54 subsequently diagnosed with breast cancer (n = 418 cases) and their matched controls...
Source: Epidemiology - Category: Epidemiology Tags: Perinatal Epidemiology Source Type: research
Conclusion: The incidence of penile and anal high-grade intraepithelial neoplasia and SCC in men with diabetes was increased compared with men without diabetes. For penile and anal SCCs, this was primarily due to an increased risk in men with T2D.
Source: Epidemiology - Category: Epidemiology Tags: Infectious Diseases Source Type: research
New UCLA-led research indicates that simple text messages emphasizing the easy availability of COVID-19 vaccines successfully boosted the number of people who got the shot.The researchers, from theDavid Geffen School of Medicine at UCLA, theUCLA Anderson School of Management and Carnegie Mellon University, say their findings held true across all demographics, including groups that have been hesitant to receive the vaccine.“We found that text messages that stressed the accessibility of the vaccine and that included ‘ownership’ language — such as ‘The vaccine has just been made available for you...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The Radiological Society of North America (RSNA) and the Society for Imagin...Read more on AuntMinnie.comRelated Reading: RSNA to launch imaging AI certificate program RSNA opens registration to 2021 conference RSNA AI challenge focuses on brain tumors SIIM, RSNA, others partner on COVID-19 AI challenge RSNA, SIIM partner on imaging informatics course SIIM announces award and prize winners
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Overall cancer rates are higher among the wealthy, finds Cancer Research UK – but smoking and its cancers are now concentrated among the poorSmoking causes almost twice as many cancer cases among the poor than the well-off, according to new findings that underline the close link between cigarettes and deprivation.About 11,247 cases of cancer caused by smoking are diagnosed among the poorest 20% of people in England each year, but far fewer – 6,200 – among those in the top 20% income bracket.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Smoking Cancer Cancer research Health Medical research Science Society UK news Source Type: news
In the busy day to day of radiology practice, it can be difficult to keep trac...Read more on AuntMinnie.comRelated Reading: CT lung cancer screening guidelines are changing Prepare now for Medicare's AUC/CDS rules for imaging orders SNMMI offers letter to contest SPECT/CT denials E/M coding and billing for interventional radiology New diagnosis codes related to COVID-19 take effect in 2021
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Advanced prostate cancer may respond to immunotherapy drugs by targeting a specific protein involved in the development of the difficult-to-treat disease, a study published by the journal Nature Cancer found.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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