Only U.S. Cryotherapy Trial for Mesothelioma Finds Success
Thoracic surgeon Dr. Shanda Blackmon at the Mayo Clinic in Rochester, Minnesota, believes there is a place for cryotherapy in the future multidisciplinary treatment of pleural mesothelioma. She wants to show it with this groundbreaking clinical trial. “We think [cryotherapy] could play an important role in treatment,” Blackmon told Asbestos.com. “So far, things look promising, but you can’t say anything specific without more numbers. Right now, it’s a little like telling a story.” Cryotherapy involves destroying cancer cells, or any abnormal tissues, by freezing them with controlled nitrogen vapors. It is often used for external tumors and applied directly with a spraying device. It also is used internally with a tube called a cryoprobe for several types of cancers and precancerous conditions. Cryotherapy is being used selectively with prostate cancer and liver cancer and still being researched for use with cancers of the colon, breast and kidneys. Cryotherapy as a Surgical Adjuvant for Mesothelioma In this mesothelioma clinical trial, cryotherapy is being tested and measured as a surgical adjuvant. The hope is that it will spark an immunological response, allowing the patient’s own immune system to better recognize and attack the tumor cells and reduce the extent of surgery. Mesothelioma is a rare and aggressive cancer that spreads quickly once it takes hold, going unrecognized by the immune system. The Mayo Clinic in Rochester is th...
A. Kumarasamy and G. A. Kurian*
P. S. Kumar* S. Durgadevi, A. Saravanan and S. Uma
T. H. Tran, Hanh Thuy Nguyen, C. S. Yong, D. H. Truong* and J. O. Kim*
A. Shirkavad, Zahra N. Borojeni and S. E. Aleyasin*
The RPS in Wales presented key recommendations from our Palliative and End of Life care policy to the Welsh Government’s End of Life Delivery Board earlier this month, a vital step in the proces
AbstractBackgrounds: The role of long non-coding RNAs (lncRNA) in gastric cancer (GC) has been highlighted in studies conducted over the past decade. However, the potential clinical value and the mechanisms of action of RP11 –6O2.4 in GC have not been thoroughly elucidated to date. The specific aim of the present study was to assess RP11–6O2.4 and to explore its role in human GC.Methods: Quantitative real-time polymerase chain reaction (qPCR) was performed to analyze the expression levels of RP11-6O2.4 in GC tissues, paired adjacent noncancerous tissues (ANTs) and GC cell lines. In addition, the correlation bet...
Conclusion: These results provide insights into the importance of chemical modification of unstable genetic therapeutics for HCC treatment. Conjugation of PEGylated GEP siRNA with ARP may be a potential HCC therapeutic agent.
AbstractPurpose of review: Exosomes are nano-sized extracellular vesicles ranging from 30 –150 nm in diameter. Exosomes interact with nearby or distantly localized recipient cells by involving ligand/receptor binding at the surface of recipient cells or fusion with plasma membrane of recipient cells. A number of recent literatures support the role of integrins in mediating metastatic p rocess of cancer cell derived exosomes. While exosomes need to dock on the surface of recipient cells to transmit signals or transfer their contents, the process of docking and uptake of exosomes by recipient cells is poorly understood...
Conclusion: Ce6-mediated PDT might be used as a potent therapeutics for AD via restoring Th1/Th2 balance and reducing over expressed immune cells.
While it is still too soon to estimate reductions in cancer, new data show that HPV vaccination significantly reduces incidence of HPV infections, high-grade cervical lesions, and anogenital warts.Medscape Medical News
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