Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson ’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that m...

Source: Molecular Neurodegeneration - February 13, 2018 Category: Neurology Authors: Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur and Byoung Dae Lee Tags: Research article Source Type: research