Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients.

CONCLUSIONS: The present study is the first to document the factorial structure of the FTD-FRS and its convergent validity with the CDR-FTLD. These tools are key to determine dementia severity in FTD. The Brazilian FTD-FRS demonstrated adequate psychometric properties for use in Brazil. This instrument may contribute to disease staging in FTD and may help to document intervention-related changes. PMID: 29438114 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Wei Li1†, Wei-Min Xiao1†, Yang-Kun Chen1*, Jian-Feng Qu1, Yong-Lin Liu1, Xue-Wen Fang2, Han-Yu Weng1 and Gen-Pei Luo11Department of Neurology, Dongguan People’s Hospital, Dongguan, China2Department of Radiology, Dongguan People’s Hospital, Dongguan, ChinaBackground: Anxiety is prevalent after a stroke. The pathophysiological mechanisms underlying the development of poststroke anxiety (PSA) remain unclear. The aim of this study was to investigate the clinical and neuroimaging risk factors for development of PSA and examine the effects of PSA on activities of daily living (ADL) and quality of life (...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, Ita...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsIn the present study, our automated classifier successfully classified FTD clinical subtypes with good to excellent accuracy. Our classifier may help clinicians diagnose FTD subtypes with subtle cortical atrophy and facilitate appropriate specific interventions.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Abstract The use of sentence repetition tasks to distinguish dementia syndromes, particularly variants of primary progressive aphasia (PPA), is receiving growing attention. Impaired sentence repetition is a core feature of logopenic variant PPA, although the underlying cognitive mechanisms of this impairment and its significance as a diagnostic criterion remain poorly understood. Sentence repetition abilities of 12 people with dementia, using an adapted error classification schema, were analyzed, along with digit span abilities, a measure frequently used to assess working memory capacity, to explore error patterns...
Source: Brain and Language - Category: Neurology Authors: Tags: Brain Lang Source Type: research
AbstractPyritinol (pyrithioxine) is a combination of two molecules of vitamin B6 (pyridoxine) with disulfide linkage. Its pharmacokinetic profile mimics that of its parent compound. Because it crosses the blood –brain barrier, its major clinical utility is in brain-related disorders. Pyritinol regulates signalling pathways of various neurotransmitters including acetylcholine, γ-aminobutyric acid,N-methyl-d-aspartate, etc. Pyritinol has also been shown to act as an antioxidant and anti-inflammatory agent, and also reduces plasma viscosity. It is indicated in paediatric populations to treat learning disabilities,...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Semin Neurol 2019; 39: 213-226 DOI: 10.1055/s-0039-1681041Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Current epidemiological data, which mostly rely on biomarker-undetermined AD cases, have highlighted ApoE4 and age as the main risk factors. Rare autosomal dominant mutations also account for a small fraction of early-onset AD. The main clinical ph...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Publication date: Available online 16 March 2019Source: NeuroImage: ClinicalAuthor(s): Suzee E. Lee, Ana C. Sias, Eena L. Kosik, Taru M. Flagan, Jersey Deng, Stephanie A. Chu, Jesse A. Brown, Anna A. Vidovszky, Eliana Marisa Ramos, Maria Luisa Gorno-Tempini, Anna M. Karydas, Giovanni Coppola, Dan H. Geschwind, Rosa Rademakers, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, William W. SeeleyAbstractMutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The objective of the study is to determine the utility of a simple reaction time task as a marker of general cognitive decline across the frontotemporal lobar degeneration (FTLD) spectrum and in Alzheimer ’s disease (AD). One hundred and twelve patients presenting with AD or FTLD affecting behaviour (behavioural-variant frontotemporal dementia), language (progressive non fluent aphasia, logopenic progressive aphasia, semantic dementia) or motor function (corticobasal syndrome, progressive supranucl ear palsy, frontotemporal dementia–motor neuron disease) and 25 age-matched healthy controls completed the Psychom...
Source: Journal of Neurology - Category: Neurology Source Type: research
Caregivers of persons with frontotemporal disorders (FTD) have unique challenges and needs. They show higher levels of stress, depression, and burden than those caring for persons with Alzheimer's disease. The clinical profiles and pathologies associated with FTD are heterogeneous and characterized by two main phenotypes: a progressive deterioration in behavior, emotion, and interpersonal conduct known as behavioral variant FTD (bvFTD) and a decline in language skills known as primary progressive aphasia (PPA).
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI - 29 Source Type: research
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