Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients.

CONCLUSIONS: The present study is the first to document the factorial structure of the FTD-FRS and its convergent validity with the CDR-FTLD. These tools are key to determine dementia severity in FTD. The Brazilian FTD-FRS demonstrated adequate psychometric properties for use in Brazil. This instrument may contribute to disease staging in FTD and may help to document intervention-related changes. PMID: 29438114 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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CONCLUSION: The present study further underlines the difficulty in clinical differential diagnosis of PPA different variants that that could evolve into AD/FTD. Brain 18F-FDG PET/CT proved valuable tool in supporting the clinical diagnosis of primary PPA eventually evolving into AD/FTD as well as in contributing to identify PPA already associated to AD/FTD since, in our cases, the diagnosis was achieved in 84.6% of both Groups. However, 18F-FDG PET/CT could not clarify the four cases with diffuse cortical hypometabolism whose diagnosis remained uncertain; only a more accurate clinical and instrumental investigation and a c...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
Conclusion: In the present study, lifetime participation in leisure time activities was found to mitigate the burden of disease in bvFTD and PPA patients. Moreover, FTD patients with a higher educational attainment were able to cope better with greater brain damage. Determination of the most suitable activities to build an adequate level of CR is crucial for dementia prevention.Neurodegener Dis 2018;18:69 –73
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
CONCLUSION: In the present study, lifetime participation in leisure time activities was found to mitigate the burden of disease in bvFTD and PPA patients. Moreover, FTD patients with a higher educational attainment were able to cope better with greater brain damage. Determination of the most suitable activities to build an adequate level of CR is crucial for dementia prevention. PMID: 29514157 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research
We present a case of memory loss and aphasia in a 72-y-old male, and discuss how PET imaging supported a diagnosis of Alzheimer's dementia despite conflicting clinical findings. PMID: 29273694 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
At a Hospital for the Mentally ill in Frankfurt, Germany, Dr. Alois Alzheimer interviewed and examined Auguste Deter; famously known as patient 'Auguste D' whose symptoms included, paranoia, aphasia and severe memory and psychosocial impairment. Keen to study the neuropathological features of her illness, Dr. Alzheimer maintained a close interest in the case of Auguste D up until her death on the 8th April 1906. On the 4th November 1906, at the 37th annual conference of South West German psychiatrists, in T übingen, Germany, Alzheimer gave a lecture titled 'Über eine eigenartige Erkrankung der Hirnrinde' (About a...
Source: Forensic Psychology Blog - Category: Forensic Medicine Source Type: blogs
Objective: To quantify the socioeconomic burden of frontotemporal degeneration (FTD) compared to previously published data for Alzheimer disease (AD). Methods: A 250-item internet survey was administered to primary caregivers of patients with behavioral-variant FTD (bvFTD), primary progressive aphasia, FTD with motor neuron disease, corticobasal syndrome, or progressive supranuclear palsy. The survey included validated scales for disease staging, behavior, activities of daily living, caregiver burden, and health economics, as well as investigator-designed questions to capture patient and caregiver experience with FTD. Re...
Source: Neurology - Category: Neurology Authors: Tags: Cost effectiveness/economic, Quality of life, All Cognitive Disorders/Dementia, Frontotemporal dementia ARTICLE Source Type: research
We examined associations between 18F‐flortaucipir and cognition in 14 mildly‐impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non‐amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic‐variant primary progressive aphasia (lvPPA, n = 4). Amnestic AD patients had deficits in memory; lvPPA in language; and both amnestic AD and PCA patients in visuospatial function. Associations with cognition were tested using sparse regression and compared to associations in anatomical regions‐...
Source: Human Brain Mapping - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractNeuropathological andin vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer ’s disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer ’s disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer...
Source: Brain - Category: Neurology Source Type: research
Conclusions All three of the canonical subtypes of FTD are associated with significant change in white matter integrity over one year. These changes are consistent enough that drug effects in future clinical trials could be detected with relatively small numbers of participants. While there are some differences in regions of change across groups, the genu of the corpus callosum is a region that could be used to track progression in studies that include all subtypes.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusions: The combination of sAPPβ with YKL-40 and with NfL in CSF could be useful to increase the certainty of the diagnosis of FTLD-related syndromes in clinical practice. Classification of evidence: This study provides Class III evidence that CSF levels of sAPPβ, YKL-40, and NfL are useful to identify patients with FTLD-related syndromes.
Source: Neurology - Category: Neurology Authors: Tags: MRI, Frontotemporal dementia, Cerebrospinal Fluid, Cognitive aging, Assessment of cognitive disorders/dementia ARTICLE Source Type: research
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