The effects of androgen deprivation therapy on pain perception, quality-of-life and depression in men with prostate cancer

Previous animal and human research suggests that testosterone has anti-nociceptive properties. Testosterone replacement in castrated male rodents and in hypogonadal men with chronic pain improves pain perception and tolerance. However, it remains unclear whether androgen deprivation therapy (ADT) – the cornerstone treatment of advanced prostate cancer (PCa) and an adjuvant therapy for high-risk disease—is associated with an increase in pain perception. Thirty-seven men with PCa about to undergo ADT with Leuprolide acetate (ADT group) were followed prospectively for 6 months to evaluate c hanges in clinical and experimental pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research