Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms

Development of chronic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) compromises the effectiveness of chemotherapies to treat cancers and greatly impacts thousands of lives. The causative mechanisms remain poorly understood. However, emerging evidence implicates unchecked neuroinflammation as a determinant factor in its development. We now demonstrate that the dysregulation of adenosine metabolism and loss of its signaling govern the extent of neuroinflammation in oxaliplatin-treated rodents.

Source: The Journal of Pain - February 14, 2018 Category: Materials Science Authors: T. Doyle, C. Wahlman, J. Little, L. Luongo, K. Janes, Z. Chen, E. Esposito, D. Tosh, S. Cuzzocrea, K. Jacobson, D. Salvemini Source Type: research