Medications That Cause Dry Mouth in Older People Medications That Cause Dry Mouth in Older People

Xerostomia, or dry mouth, is one of the most common adverse effects of medication use in older adults. Which classes of drugs are most problematic, and how great is the risk?Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

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ConclusionsAdaptive two-step IMRT for NPC demonstrated an excellent 3-year OS with acceptable toxicities. This method may be one treatment option for locally advanced NPC.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients.MethodThe data of 352 pSS patients were analyzed retrospectively. The patients were divided into two groups as those with the onset age of 35 or younger (early-onset) and those with the onset age of older than 35. The clinical, laboratory, and serological characteristics of the two groups were compared.p 
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conditions:   Xerostomia;   Hyposalivation Intervention:   Device: Biotene® Oralbalance Moisturizing Gel Sponsors:   Nova Scotia Health Authority;   Dalhousie University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750-1,000 ml of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycopr...
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research
This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years (SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years (SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical ev...
Source: American Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Tags: Am J Speech Lang Pathol Source Type: research
Xerostomia, dry mouth, is one of the most common complications during and after radiotherapy for head and neck cancers due to terminal damage to the salivary glands. Xerostomia often contributes to both minor and serious health problems, which severely decrease quality of life for patients. Current methods of management and preventative measures of xerostomia have shown little success and effectiveness. Like all tissues, salivary glands are maintained by a small group of cells, stem/progenitor cells, with the capacity to repopulate and differentiate into the needed cell types upon tissue injury.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
To determine whether the radiation (RT) dose to the parotid gland stem cell (SC) region or pre- and mid-treatment CT scans as well as change in parotid gland volume is associated with long-term patient-reported xerostomia after definitive head and neck cancer (HNC) RT.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
Salivary gland hypofunction and xerostomia remain major obstacles after radiation of head and neck cancers. There is large unmet need for new treatment strategies as only insufficient symptomatic therapies exits. The randomized controlled MESRIX-trial indicates that autologous adipose-derived mesenchymal stem/stromal cells (ASCs) can safely restore function of the irradiated submandibular glands in former oropharynx cancer patients. Allogeneic ASCs from healthy donors as a ready-to-use therapies have been proved safe for several diseases and may be a new intervention for radiation-induced xerostomia.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
CONCLUSIONS: The genital disorders secondary to SS can strongly alter the quality of female life both physically and psychologically as they alter sexuality. However, the observation of certain behavioral norms and the use of appropriate local substances can alleviate the symptoms and effectively contribute to reducing the discomfort. PMID: 32153164 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
Abstract This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients. A systematic literature review was performed to retrieve NTCP models for HNC toxicities. Patient population characteristics, NTCP model and the predictors, treatment technique and endpoint definition were extracted per article. Models were then scored based on the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) consensus guidelines to evaluate their generalizability. 335 articles on photon...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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