FOXO in Neural Cells and Diseases of the Nervous System.
FOXO in Neural Cells and Diseases of the Nervous System. Curr Top Dev Biol. 2018;127:105-118 Authors: Santo EE, Paik J Abstract The evolutionarily conserved FOXO family of transcription factors has emerged as a significant arbiter of neural cell fate and function in mammals. From the neural stem cell (NSC) state through mature neurons under both physiological and pathological conditions, they have been found to modulate neural cell survival, stress responses, lineage commitment, and neuronal signaling. Lineage-specific FOXO knockout mice have provided an invaluable tool for the dissection of FOXO biology in the nervous system. Within the NSC compartments of the brain, FOXOs are required for the maintenance of NSC quiescence and for the clearance of reactive oxygen species. Within mature neurons, FOXO transcriptional activity is essential for the prevention of age-dependent axonal degeneration. Acutely, FOXO3 has been found to cause axonal degeneration upon withdrawal of neurotrophic factors. In more active neural signaling, FOXO6 promotes increased dendritic spine density of hippocampal neurons and is required for the consolidation of memories. In addition to the central nervous system (CNS), FOXOs also influence the functionality of the peripheral nervous system (PNS). FOXO1 knockout within the PNS results in a reduction of sympathetic tone and decreased levels of brain-derived norepinephrine and lower energy expenditure. FOXO3 knockout mice have impair...
Conclusion: Physical exercise contributes effectively to the treatment of PD, and can play a preventive and maintenance role of physical fitness and mental health. PMID: 29785199 [PubMed]
Matej Skorvanek, Eva Feketeova, Monica M. Kurtis, Jan Rusz, Karel Sonka
Yonglu Huang, Joshua P. Aronson, Julie G. Pilitsis, Lucy Gee, Jennifer Durphy, Eric Steven Molho, Adolfo Ramirez-Zamora
Clovis Chabert, Camille Laporte, Arnold Fertin, Emily Tubbs, C écile Cottet-Rousselle, Florence Rivera, Magali Orhant-Prioux, Anaick Moisan, Eric Fontaine, Pierre-Yves Benhamou, Sandrine Lablanche
We report here that tau interacts with the Ca2+-regulated plasma membrane–binding protein annexin A2 (AnxA2) via tau's extreme N terminus encoded by the first exon (E1). Bioinformatics analysis identified two conserved eight-amino-acids-long motifs within E1 in mammals. Using a heterologous yeast system, we found that disease-related mutations and pseudophosphorylation of Tyr-18, located within E1 but outside of the two conserved regions, do not influence tau's interaction with AnxA2. We further observed that tau interacts with the core domain of AnxA2 in a Ca2+-induced open conformation and interacts also with AnxA6...
In conclusion, MSC differentiation into SMCs is regulated by miR-503 and miR-222-5p and yields functional SMCs for use in vascular grafts.
α-Synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, are thought to be involved in the pathogenesis of Lewy body diseases, such as Parkinson's disease (PD). Although growing evidence suggests that cell-to-cell transmission of α-Syn is associated with the progression of PD and that extracellular α-Syn promotes formation of inclusion bodies, its precise mechanism of action in the extracellular space remains unclear. Here, as indicated by both conventional fractionation techniques and FRET-based protein–protein interaction analysis, we demonstrate that extracellular &al...
Human Brain Mapping, EarlyView.
Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse modelCorrection to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model, Published online: 25 May 2018; doi:10.1038/s41419-018-0636-4Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP01631C, PaperYibo Jin, Yunxiang Sun, Jiangtao Lei, Guanghong Wei Alzheimer's disease (AD) is associated with the aggregation of amyloid-[small beta] (A[small beta]) peptides into toxic fibrillar aggregates. Finding effective inhibitors of A[small beta] aggregation is a crucial step for the development of... The content of this RSS Feed (c) The Royal Society of Chemistry