Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release

Ammonium has repeatedly been found a key factor in the pathogenesis of hepatic encephalopathy (HE) [1] and development of brain edema (BE) in acute liver failure [2]. Yet, the underlying mechanisms are still not understood in detail, specifically a mediator responsible for disturbances in the microcirculation and vasodilatation remains to be identified.

Source: Journal of Hepatology - February 13, 2018 Category: Gastroenterology Authors: Peter Nissen Bjerring, Esben Jannik Bjerrum, Fin Stolze Larsen Source Type: research