SNX10 mediates alcohol-induced liver injury and steatosis via regulating chaperone-mediated autophagy activation.

Alcoholic liver disease (ALD) is a spectrum of disorders ranging from reversible steatosis to life-threatening and irreversible cirrhosis, and in few percent cases hepatocellular cancer [1]. Alcohol exposure induces oxidative stress and mitochondrial dysfunction, which leads to hepatocyte apoptosis, necrosis, and necroptosis, as well as hepatic inflammation. In addition, ethanol consumption disrupts lipid metabolism and subsequently accumulates excessive triglycerides in the liver, further aggravating liver injury [2].

Source: Journal of Hepatology - February 13, 2018 Category: Gastroenterology Authors: Yan You, Wan-Zhen Li, Sulin Zhang, Bin Hu, Yue-Xuan Li, Hai-Dong Li, Huan-Huan Tang, Qian-Wen Li, Yun-Yun Guan, Li-Xin Liu, Wei-Lian Bao, Xiaoyan Shen Source Type: research