Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy
Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Yun-kai Lin, Zheng Fang, Tian-yi Jiang, Zheng-hua Wan, Yu-fei Pan, Yun-han Ma, Yuan-yuan Shi, Ye-xiong Tan, Li-wei Dong, Yong-jie Zhang, Hong-yang Wang Tags: Original Articles Source Type: research
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