Rise in Canadian Obesity Rate May Lead to Higher Cancer Burden

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Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research

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Authors: Román GC, Jackson RE, Reis J, Román AN, Toledo JB, Toledo E Abstract Observational epidemiological studies provide valuable information regarding naturally occurring protective factors observed in populations with very low prevalences of vascular disease. Between 1935 and 1965, the Italian-American inhabitants of Roseto (Pennsylvania, USA) observed a traditional Italian diet and maintained half the mortality rates from myocardial infarction compared with neighboring cities. In the Seven Countries Study, during 40years (1960-2000) Crete maintained the lowest overall mortality rates and coronar...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
CONCLUSIONS: Epidemiological figures emerging from this study confirm that trends in Lebanon are in line with a global pattern of decreasing age at menarche. Urban-rural differences suggest that higher caloric content of diet and consequent early overweight, more evident in urban areas, are likely determinants of younger menarche. Evidence from this study calls for an urgent implementation of comprehensive multisectoral obesity prevention in children in Lebanon. PMID: 31519350 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Authors: Li X, Liu M, Ji JY Abstract Multiple large-scale epidemiological studies have identified obesity as an important risk factor for a variety of human cancers, particularly cancers of the uterus, gallbladder, kidney, liver, colon, and ovary, but there is much uncertainty regarding how obesity increases the cancer risks. Given that obesity has been consistently identified as a major risk factor for uterine tumors, the most common malignancies of the female reproductive system, we use uterine tumors as a pathological context to survey the relevant literature and propose a novel hypothesis: chronic downregulatio...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
People with poor lifestyle and obesity are at greater risk of incident T2D – regardless of their genetic risk Related items fromOnMedica Majority of patients ignorant of obesity link to cancer Health system ‘all too often’ lets down people with diabetes Many patients ignore symptoms of diabetes Annual diabetes checks still being missed Tackling obesity ‘must be made a national priority’
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractArchaea, which form one of four domains of life alongside Eukarya, Bacteria, and giant viruses, have long been neglected as components of the human microbiota and potential opportunistic infectious pathogens. In this review, we focus on methanogenic Archaea, which rely on hydrogen for their metabolism and growth. On one hand, methanogenic Archaea in the gut are functional associates of the fermentative digestion of dietary fibers, favoring the production of beneficial short-chain fatty acids and likely contributing to the weaning reaction during the neonatal window of opportunity. On the other hand, methanogenic Ar...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Authors: Skonieczna M, Hudy D, Hejmo T, Buldak RJ, Adamiec M, Kukla M Abstract BACKGROUND: Among adipose-derived factors, adipocytokines play roles as hormones and signaling mediators for apoptotic pathway. Among of them, vaspin, regulates the metabolism of adipose tissue itself as an endocrine organ, and stimulates adipocytes to maturation, differentiation, etc. Damaged adipocytes, present in obesity and hepatocellular carcinoma (HCC) respond with over-production of inflammatory cytokines. Such pro-inflammatory stimulation remains under adipokine control. Pro-inflammatory pathways are connected to oxidative stress...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
'Sensibly optimistic systematic review does not provide definitive evidence that true incidence is falling ’ Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Obesity as cause of cancer set to overtake smoking Should we recognise obesity as a disease? Type 2 diabetes in 10 times more young people than realised Even athletes can ’t outrun the effects of a bad diet
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionOur study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2  probably serves not only as a diagnostic biomarker, but also a new therapeutic target.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Hoskin Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells was determined and compared with the effect of AF4 on normal mammary epithelial cells and dermal fibroblasts. AF4 inhibited breast cancer cell growth in monolayer cultures, as well as the growth of MCF-7 spheroids, without substantially affecting the viability of non-malignant cells. A sub-cytotoxic concentration of AF4 suppressed the proliferation of MDA-MB-23...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Obesity-Associated Cancer Shifting to Younger People
Source: eMedicineHealth.com - Category: General Medicine Source Type: news
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