E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor

ILC2s are critically involved in allergic responses, but the mechanisms by which they are regulated remain unclear. Li et  al. demonstrate that the VHL-HIF axis is essential for ILC2 maturation and function via inhibition of glycolysis and induction of IL-33 receptor expression. These findings have implications for identifying therapeutic targets for allergic diseases.

Source: Immunity - February 13, 2018 Category: Allergy & Immunology Authors: Qian Li, Dulei Li, Xian Zhang, Qingqing Wan, Wen Zhang, Mingke Zheng, Le Zou, Chris Elly, Jee H. Lee, Yun-Cai Liu Tags: Article Source Type: research