Formation of osteon ‐like structures in unidirectional porous hydroxyapatite substitute

The objectives of the present study were to assess the vasculature and microstructure of newly formed bone and to determine how bone formation is affected by load transfer and UDPHAp pore size. Formation of osteon‐like structures, defined by the presence of lacunae, canaliculi and a central lumen containing capillaries, was observed within the implanted UDPHAp material in all animals after six weeks. The number of osteocytes and osteon‐like structures in areas adjacent to the cortex of recipient bone was significantly higher than in areas next to the medullary cavity throughout the recovery period. Notably, osteon‐like structures tended to form in smaller diameter pores. Continuous bone remodeling might be promoted by the rapid formation of unidirectional capillaries and the osteocyte lacunae‐canalicular system. Load transfer and smaller pore size could positively affect cortical bone regeneration. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 1, 2018 Category: Materials Science Authors: Takeshi Makihara, Masataka Sakane, Hiroshi Noguchi, Toshinori Tsukanishi, Yasushi Suetsugu, Masashi Yamazaki Tags: Original Research Report Source Type: research