Mixed Results with PD Drug in Alzheimer's Psychosis (CME/CE)

(MedPage Today) -- Six-week improvement with pimavanserin didn't endure at 12 weeks
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news

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Authors: An L, Adeli E, Liu M, Zhang J, Shen D Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs a patient's memory and other important mental functions. In this paper, we leverage the mutually informative and complementary features from both structural magnetic resonance imaging (MRI) and single nucleotide polymorphism (SNP) for improving the diagnosis. Due to the feature redundancy and sample outliers, direct use of all training data may lead to suboptimal performance in classification. In addition, as redundant features are involved, the most discriminative feature subset ...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
STATE HOUSE, BOSTON, August 15, 2018 (State House News Service) — A new state law aims to change the way Alzheimer’s Disease diagnoses and treatment are handled in Massachusetts in hopes of addressing what one advocate said is currently the “single largest unaddressed public health threat.” The law, which Gov. Charlie Baker signed on Aug. 9 and marked with a ceremonial signing on Wednesday, requires the creation of an “integrated state plan to address and assist in the treatment of Alzheimer’s disease,” establishes an advisory council on research and treatment, and calls upon docto...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Alzheimer's Disease Local TV Source Type: news
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01205A, PaperMaria Paraskevaidi, Camilo Morais, Daniel L. D. Freitas, Kassio Michell Gomes de Lima, David M. A Mann, David Allsop, Pierre L Martin-Hirsch, Francis L Martin Alzheimer ’s disease (AD) is currently under-diagnosed and is predicted to affect a great number of people in the future, due to the unrestrained aging of the population. An accurate diagnosis... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Conditions:   Dementia Alzheimers;   Dementia;   Dementia, Vascular;   Dementia Senile Intervention:   Sponsor:   Moorfields Eye Hospital NHS Foundation Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: This study showed that the mixture analysis can refine the ideal cut-off for defining LOAD as a homogeneous genetic entity. We also validated the e4 allele anticipatory effect only in LOAD. In summary, the tool developed in this study is a sophisticated statistical pipeline to analyze the AAO in genome-wide association studies of AD, to find new molecular targets as a new line of translational research to foster drug discovery.Neuropsychobiology
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
Conclusion: This meta-analysis confirmed the association between sleep and cognitive impairment or AD and, for the first time, consolidated the evidence to provide an “average” magnitude of effect. As sleep problems are of a growing concern in the population, these findings are of interest for potential prevention of AD. The Study in Context: Bill Gates announces $50 million investment to fight Alzheimer’s Disease From Anti-Alzheimer’s ‘Magic Bullets’ to True Brain Health 10 million people develop dementia every year Report: 35% of worldwide dementia cases could be prevented by modifyi...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Alzheimer’s Disease cognitive problems cognitive-decline dementia sleep sleep apnea sleep disorders sleep parameters sleep problems Source Type: blogs
Theory and evidence for persistent infection as a cause of Alzheimer's disease continues to grow in scope and plausibility. In general this supports rather than replaces past thinking on amyloid-β and its role in the development of Alzheimer's. It provides an explanation as to why it is that levels of amyloid-β rise over time to produce the early disruptions and changes in the biochemistry of the brain that are necessary for later neurodegeneration to take place. Other compelling lines of work provide evidence for entirely separate mechanisms by which levels of amyloid-β can grow in later life, such as decli...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: Available online 15 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Angélica Torres-Berrio, Mauricio O. Nava-MesaAbstractCognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS In a transgenic mouse model of AD, miR-137 and expression of the CACNA1C gene inhibited the hyperphosphorylation of tau protein. PMID: 30102687 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Frustrated caregivers often wonder why their loved one who is living with Alzheimer’s sometimes reacts with anger as the caregivers attempt to help. Understanding why a spouse, parent or grandparent behaves this way can help the caregiver limit these stressful, frustrating times. To do that, the caregivers must understand life from the point of view of their loved one’s impaired mind. View slideshow on HealthCentral with tips to help you understand your loved one's anger: MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in support groups with real stories - for bulk...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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