Downregulation of PRAME Suppresses Proliferation and Promotes Apoptosis in Hepatocellular Carcinoma Through the Activation of P53 Mediated Pathway

Conclusions: In HCC, PRAME serves as a potential biomarker for poor prognosis and novel therapeutic target in treating this cancer. PRAME is a potential biomarker of poor prognosis in HCC. PRAME surpresses HCC cell deathin vitro andin vivo by regulating p53 apoptotic signaling and may serve as a potential therapeutic target in HCC.Cell Physiol Biochem 2018;45:1121 –1135
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research