Inhibition of Suicidal Erythrocyte Death by Indirubin-3 ’-Monoxime

Conclusions: IDM is a novel inhibitor of suicidal erythrocyte death following ionomycin treatment, t-BHP treatment and energy depletion. Thus, IDM may counteract anemia and impairment of microcirculation, at least in part, by inhibition of Ca2+ entry into erythrocytes.Cell Physiol Biochem 2018;45:1108 –1120
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research

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Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure.Now, a UCLA-led research team has developed a spray gel embedded with immune-boosting drugs that could help. In a peer-reviewed study, the substance was successful half of the time in awakening lab animals ’ immune systems ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Fresenius Medical Care is letting it be known that it wants to have a stronger presence in China, one of the fast-growing emerging markets. Last week the Bad Homberg, Germany-based company announced a ton of acquisitions and investments in dialysis centers and renal hospitals in China. Here’s the breakdown: The company acquired a 70% share of Guangzhou KangNiDaiSi Medical Investment Co., Ltd, which focuses on dialysis and related chronic disease services. KangNiDaiSi has three independent hemodialysis centers under construction in the cities of Guangzhou and Zhaoqing in Guangdong province, which borders H...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Publication date: Available online 10 December 2018Source: Journal of Pharmacological SciencesAuthor(s): Muneyoshi Okada, Hideyuki YamawakiAbstractType IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. The anti-angiogenic effect of canstatin may be also useful for the treatment of ocular neovasculariz...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
ConclusionsAn SBRT boost dose of 30 Gy can be delivered without compromising QUANTEC OAR limits. The use of SBRT increases TCP values, regardless of the input parameters.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 9 December 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Jean El-Cheikh, Rana Salem, Radwan Massoud, Charelle Salem, Nohra Ghaoui, Souha S. Kanj, Rami Mahfouz, Ali Bazarbachi
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
If you experience depression, you will typically be prescribed an antidepressant, an SSRI or other agent, and have to endure the common side-effects such as weight gain, aggression, anxiety, suicidal thoughts, and erectile dysfunction. If you consult a psychologist or counselor, the underlying psychological underpinnings (if any) are explored, strategies devised to cope. But there will almost never be talk about your diet, nutritional deficiencies that amplify dark moods, or the microbiome. Yet there are very powerful strategies available that have potential to substantially lift mood. Such solutions won’t, of course...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates anxiety bowel flora Depression Gliadin gluten-free grain-free grains Inflammation mood wheat belly Source Type: blogs
This study investigated differences in psychiatric outcomes and adverse effects between different frequencies of depot antipsychotics through a systematic review and meta-analysis. We performed a systematic search of MEDLINE, EMBASE, Cochrane database, PsycINFO and two Chinese databases for RCTs that compared the frequency of depot antipsychotic administration. The primary outcome was psychiatric symptomatology, with secondary outcomes of quality of life, admission rates, adverse drug reactions, cost-effectiveness and compliance. Twelve studies were included in the meta-analysis. Most studies compared two- and four-weekly ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Funding Opportunity RFA-DK-18-030 from the NIH Guide for Grants and Contracts. Pain is a common problem in Medicare End-Stage Renal Disease (ESRD) Hemodialysis (HD) patients, but its prevalence varies widely by geography, dialysis unit, and possibly, ethnicity. Pain has been linked to decreased quality of life, lack of social support, depressed mood and other mental health disorders. Chronic opioid prescription has been identified in approximately 20% of US ESRD HD patients, far higher than in Medicare comparison populations. Opioid doses prescribed to HD patients exceed Centers for Disease Control and Prevention (CDC) re...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity RFA-DK-18-031 from the NIH Guide for Grants and Contracts. Pain is a common problem in Medicare End-Stage Renal Disease (ESRD) Hemodialysis (HD) patients, but its prevalence varies widely by geography, dialysis unit, and possibly, ethnicity. Perception of pain has been linked to decreased quality of life, lack of social support, depressed mood and other mental health disorders. Chronic opioid prescription has been identified in approximately 20% of US ESRD HD patients, far higher than the rate in Medicare comparison populations. Opioid doses prescribed to HD patients exceed Centers for Disease Control ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Conditions:   Chronic Lymphocytic Leukemia (CLL);   Waldenstrom Macroglobulinemia (WM) Intervention:   Drug: Shingrix vaccine Sponsor:   University of Rochester Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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