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Inhibition of Suicidal Erythrocyte Death by Indirubin-3 ’-Monoxime

Conclusions: IDM is a novel inhibitor of suicidal erythrocyte death following ionomycin treatment, t-BHP treatment and energy depletion. Thus, IDM may counteract anemia and impairment of microcirculation, at least in part, by inhibition of Ca2+ entry into erythrocytes.Cell Physiol Biochem 2018;45:1108 –1120
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research

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Authors: Yu HX, Han CS, Xue JR, Han ZF, Xin H Abstract INTRODUCTION: Esophageal hiatal hernia involves abnormal abdominal entry into thoracic cavity. It is classified based on orientation between esophageal junction and diaphragm. Sliding hiatal hernia (Type-I) comprises the most frequent category, emanating from right crus of diaphragm. Type-II esophageal hernia engages both left and right muscular crura. Type-III and IV additionally include the left crus. Age and increased body mass index are key risk factors, and congenital skeletal aberrations trigger pathogenesis through intestinal malrotations. Familiar manif...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Conclusions Although the RCA model offers a formal and systematic approach to the review of serious critical incidents in mental health, it is not the model of best fit. Only 65% of recommendations made through RCA reviews are implemented within 12 months.
Source: Journal of Patient Safety - Category: Health Management Tags: Original Articles Source Type: research
A patient sent me this emailI had a query. I have conceived through IVF and ET was on Jan 6 th and my LMP was on Dec 20th.I got my ultrasound done on 16th Feb and in scan it showed the pregnancy is 5 weeks 6 days.If I calculate the growth of the baby from the date of the transfer, this seems fine, but if I calculate from the date of the LMP , it seems to be lagging behind.I am completely confused - can you please help ?This is a common problem, because IVF patients use their common sense and assume that doctors would calculate pregnancy dates based on the age of the embryo. Since they know the date of the embryo transfer, ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Authors: Liu Y, Chen X, Han W, Zhang Y Abstract On August 30, 2017, the U.S. Food and Drug Administration (FDA) approved Novartis' tisagenlecleucel (CTL-019, Kymriah), which is a synthetic bioimmune product of anti-CD19 chimeric antigen receptor (CAR) T cells, for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). This was a milestone in tumor immunology on account of the significant antitumor effect of tisagenlecleucel for the treatment of relapsed/refractory B-ALL patients. Conventional standard therapies for B-ALL have high failure rates, thus developing new therapies is crucial fo...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
We report an unusual case of large Brunner's gland hyperplasia in 72-years old man, admitted to hospital for epigastric pain, recurrent vomiting and significantly weight loss. Upper endoscopy showed an obstructive submucosis tumour of the bulb. Abdominal computed tomography scan revealed a circumferential thickening and stenosing mass of the first part of the duodenum leading to severe obstruction. Though pre-operative biopsies were negative, imaging studies and endoscopy were strongly suggestive of malignancy and the patient underwent duodenocephalopancreatectomy. Brunner's gland hyperplasia may have unusual presentation,...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
We report an ALK-rearranged adenocarcinoma of the lung presenting as a pituitary metastasis, clinically simulating a pituitary adenoma. The patient, a 50 year-old, former-smoking woman was admitted with a Parinaud's syndrome characterized by progressive oculomotor impairment of visual verticality, bitemporal hemianopsia and nystagmus. Imaging studies showed a sellar tumor and the biopsy revealed a TTF-1 and napsin positive lung adenocarcinoma strongly expressing synaptophysin and CD56, also harboring ALK rearrangement. A subsequent CT scan disclosed the primary lung mass of the left upper lobe. The patient progressed after...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
We present the case of a 81 years old women previously treated for cervix carcinoma showing later a stomach metastasis. The patient is alive and disease free 39 months after salvage gastrectomy. A radical surgery in selected patients could be useful for symptom palliation and prolonged survival. PMID: 29449732 [PubMed - in process]
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
Depression is the leading cause of disability worldwide
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
CONCLUSIONS: The ways in which mental health care providers think about suicide and make sense of their experiences affects their perceived abilities to prevent suicide. Educating mental health care providers to transcend the limitations of risk factor approaches to suicide prevention and utilise evidence-based strategies for treating substance use disorders and associated problems, may be important to empower them and make them feel competent in suicide prevention. Empowering people with substance use disorders may help prevent suicide and may require collaboration between mental health care providers and allied professio...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
AbstractAn index case of Legionnaires ’s disease with mediastinal adenopathy prompted us to review our recent experience with Legionnaires’ disease to determine the incidence of mediastinal adenopathy of this finding in Legionnaires’ disease. We reviewed the radiographic findings of 90 hospitalized adults with Legionnaires’ dise ase from 2015 to 2017. Excluded were 11 patients with mediastinal adenopathy due to non-Legionnaires’ disease causes, e.g., lymphoma. Thirty-seven of the remaining patients had both chest films and chest computed tomography (CT) scans. Of the 37 Legionnaires’ dis...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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