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Merck scraps another late-stage Alzheimer's drug study

NEW YORK (Reuters) - Merck&Co Inc on Tuesday said it will end another late-stage trial of an Alzheimer's drug because it was unlikely to work, adding to the pile-up of failures to find an effective treatment for the mind-wasting disease.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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In this issue of Parkinsonism and Related Disorders, two studies address the role of biomarkers for atypical parkinsonian syndromes. Interest in testing experimental treatments for disorders like Multiple Systems Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) has increased recently [1,2], both to meet the needs of patients with these disorders and because they can be thought of as model systems for more common conditions, like Alzheimer's disease. Understanding how to use biomarkers for atypical parkinsonian syndromes is a crucial step in this process.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Editorial Source Type: research
Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.Dement Geriatr Cogn Disord Extra 2018;8:51 –59
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
Authors: Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D Abstract Mitochondrial dynamics, involving a balance between fusion and fission, regulates mitochondrial quality and number. Increasing evidence suggests that dysfunctional mitochondria play a role in Alzheimer's disease (AD). We observed that Drp1 interaction with one of the adaptors, Fis1, is significantly increased in Aβ-treated neurons and AD patient-derived fibroblasts. P110, a seven-amino acid peptide, which specifically inhibits Drp1/Fis1 interaction without affecting the interaction of Drp1 with its other adaptors, attenuated Aβ42-induced mitoch...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Yang L, Bhattacharya A, Li Y, Zhang Y Abstract We recently discovered a plasma proteolysis pathway, termed the FXII-FVII pathway which is composed of coagulation proteases, and found it to be mainly responsible for the clearance of Aβ42 in the plasma in mice. Aβ42 and Aβ40 are the main Aβ forms in Alzheimer's disease (AD). In the present study, in vitro assays, wild type (WT) mice and J20 mice (a transgenic AD model) are used to assess the degradation of Aβ40 and Aβ42 by the FXII-FVII pathway and the impact of anticoagulants on such degradation. Four clinically available and m...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Nothing can make it easy for us to watch the cognitive decline of someone we love. Nothing will take away the agony of seeing loved ones so changed from the individuals they used to be. But imaginatively entering into their world is the most effective way to survive, and occasionally enjoy, the world of dementia caregiving. View slideshow on HealthCentral to learn more about having some fun while caregiving: Purchase Minding Our Elders: Caregivers Share Their Personal Stories – paperback or ebook Minding Our Elders lets you know that you are not alone, that you are not going to be perfect, but you can get the job don...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Conclusions The present study demonstrated for the first time that AOF attenuated LPS-induced learning and memory impairment, which may be associated with its inhibitory effect on neuroinflammation, amyloids-β (Aβ) deposition and p-tau. This research provided a theoretical basis for elucidating the traditional theory of AOF, and was also the stepping stone to the next step. Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 148 Author(s): Susana Carmona, John Hardy, Rita Guerreiro Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common form of dementia with high incidence in elderly people. Neuropathologically the disease is defined by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles of phosphorylated tau protein. Genetically, the first clues were provided by genetic linkage studies that led to the identification of APP, PSEN1, and PSEN2 mutations as the main causes of autosomal-d...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
There are around 5.5 million Americans living with Alzheimer's and deaths have almost doubled in two decades. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: Self-Acceptance Practices For Emotional Healing Activate: How To Find Joy Again By Changing What You Do The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
Hot on the heels of headlines linking alcohol consumption with longer life comes new research that casts a much more sobering light on drinking. According to an analysis of more than 1 million people—the largest study of its kind to date—scientists say that heavy alcohol use is the biggest modifiable risk factor for dementia, especially early-onset forms of the disease. The findings, which are published in The Lancet Public Health, came as a shock to the researchers involved. “We hypothesized that alcohol would play some role, but I don’t think anyone expected the size of the effect to be so large,&...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
To evaluate whether drugs with serotonergic activity, alone or in combination, are a risk factor for antipsychotic prescribing among long-term care (LTC) residents. The secondary objective was to evaluate that same risk among residents with dementia or Alzheimer ’s disease.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Research Source Type: research
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