Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl.

Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Intern Med. 2018 Feb 09;: Authors: Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R Abstract We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger. PMID: 29434138 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research

Related Links:

Cancer-fighting Five Prime Therapeutics Inc. will cut about 20 percent of its 209-person workforce as it tries to push more drugs into clinical trials and advance those already being tested on patients. The move — the first large-scale layoff in the South San Francisco biotech company's 17 years — comes during a sustained push by Five Prime (NASDAQ: FPRX) into cancer immunotherapy, where drugs are used to rally the immune system to battle cancer. The job cuts, starting today, include researc h,…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Publication date: Available online 14 January 2019Source: International Journal of PharmaceuticsAuthor(s): Huangliang Zheng, Jiaqi Li, Mengjing Wang, Xiang Luo, Qiujun Qiu, Ling Hu, Cong LI, Yanzhi Song, Yihui DengAbstractTo overstep the dilemma of chemical drug degradation within powerful lysosomes of tumor associated macrophages (TAMs), a sialic acid-polyethylenimine-cholesterol (SA-PEI-CH) modified liposomal doxorubicin (DOX-SPCL) was designed with both TAMs targeting and smart lysosomal trafficking. The modified liposome DOX-SPCL performed particle size as 103.2 ± 3.1 nm and zeta potential as -4.5 ± 0.9 m...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Liver Cancer 2019;8:1 –11
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
Publication date: 14 January 2019Source: Cancer Cell, Volume 35, Issue 1Author(s): Arnold J. Levine, Nancy A. Jenkins, Neal G. CopelandWe propose that initiating truncal mutations plays a special role in tumor formation by both enhancing the survival of the initiating cancer cell and by selecting for secondary mutations that contribute to tumor progression, and that these mutations often act in a tissue-preferred fashion. Here, we explain why inherited mutations often have different tissue specificities compared with spontaneous mutations in the same gene. Initiating truncal mutations make excellent neo-antigens for immuno...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
CONCLUSION: This review summarizing antigens and approaches to overcome defects of CAR T cell immunotherapy from patents and publications might contribute to broad readership. PMID: 30636615 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
Authors: De Marinis F, Barberis M, Barbieri V, Marchianò A, Gasparini S, Migliorino MR, Romano G, Spinnato F, Vitiello F, Gridelli C Abstract INTRODUCTION: In the era of personalized cancer therapy, the sampling of adequate tumor tissue for histologic diagnosis and genomic profiling is crucial, not only at the initial diagnosis but also in the event of resistant and recurrent disease when sequential biopsies may be required to evaluate somatic mutations and histologic changes. Areas covered: The identification of genetic driver alterations led to the selection of patients who are most likely to benefit from ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 15 January 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Chunhui Duan, Dandan Hu, Xinming Tang, Jingxia Suo, Si wang, Sixin Zhang, Geru Tao, Chao Li, Chaoyue Wang, Xiaolong Gu, Xiaoli Tang, Guangping Huang, Biqi Xiang, Shaoqiang Wu, Choukri Ben Mamoun, Xun Suo, Xianyong LiuAbstractEimeria spp., the causative agents of coccidiosis, are the most common protozoan pathogens of chickens. Infection with these parasites can result in poor development or death of animals leading to a devastating economic impact on poultry production. The establishment of transfection protocols for ...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Adriana E Kajon, Daryl M Lamson, Kirsten St. GeorgeHuman adenoviruses (HAdVs) are prevalent causes of acute respiratory disease (ARD) in military and civilian communities. Over the last 20 years, collaborative efforts between US public health, military and academic laboratories have gathered comprehensive data documenting the emergence and re-emergence of specific HAdV types in association with outbreaks and unrelated cases of ARD, which have attracted national attention. New or reemerging HAdVs have included genomic variants of HAdV-B1...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Nigel James Maclachlan, Stephan Zientara, William C Wilson, Juergen A Richt, Giovanni SaviniBluetongue (BT) and epizootic hemorrhagic disease (EHD) are globally re-emerging diseases of domestic and wild ruminants, respectively caused by BT virus (BTV) and EHD virus. Both viruses are transmitted by hematophagous midges; however, newly recognized BTV serotypes may be transmitted horizontally without requirement for any biological vector. The global range of these viruses and/or their associated diseases have changed remarkably in recent y...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Qiuhong Wang, Anastasia N Vlasova, Scott P Kenney, Linda J SaifPorcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV) are emerging/reemerging coronaviruses (CoVs). They cause acute gastroenteritis in neonatal piglets. Sequence analyses suggest that PEDV and SADS-CoV may have originated from bat CoVs and PDCoV from a sparrow CoV, reaffirming the interspecies transmission of CoVs. The clinical signs and pathogenesis of the three viruses are similar. Necrosis of in...
Source: Current Opinion in Virology - Category: Virology Source Type: research
More News: ALS | Brain | Cervical Cancer Vaccine | Genetics | Girls | Human Papillomavirus (HPV) | Immunotherapy | Internal Medicine | Neurology | Respiratory Medicine | Sarcomas | Vaccines