Statistical tests and identifiability conditions for pooling and analyzing multisite datasets Statistics

When sample sizes are small, the ability to identify weak (but scientifically interesting) associations between a set of predictors and a response may be enhanced by pooling existing datasets. However, variations in acquisition methods and the distribution of participants or observations between datasets, especially due to the distributional shifts in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physical Sciences Source Type: research

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Authors: Yin Y, Wang Z Abstract Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: ɛ2, ɛ3, and ɛ4. Among the three polymorphic alleles, apoE ε4 is the most risk gene. ApoE is the main ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP), functioning as the component of plasma lipoproteins in the transportation of lipids. Physiologically, ApoE is a multifunc...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionA new robust and reliable rating scale is described that straightforwardly captures the visual appearance of 123I-Ioflupane brain images. It demonstrated high accuracy in autopsy confirmed cases and offers advantages over the existing visual rating scale.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
As the American population both grows and ages, the Centers for Disease Control and Prevention warns that 13.9 million people will be diagnosed with Alzheimer's by 2060.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
As the aging population of the United States grows, a new study from the US Centers for Disease Control and Prevention says that from 2014 to 2060, there will be a 178% increase in the number of Americans who have Alzheimer's disease and related dementias.
Source: - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 20 September 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Stefano Porcelli, Nic Van Der Wee, Steven van der Werff, Moji Aghajani, Jeffrey C. Glennon, Sabrina van Heukelum, Floriana Mogavero, Antonio Lobo, Francisco Javier Olivera, Elena Lobo, Mar Posadas, Juergen Dukart, Rouba Kozak, Estibaliz Arce, Arfan Ikram, Jacob Vorstman, Amy Bilderbeck, Ilja Saris, Martien J. Kas, Alessandro SerrettiAbstractThe human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms th...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Dementia UK has revealed people diagnosed with Alzheimer's are most often worried about having to stop driving, giving up work, losing their memory and needing someone to manage their money.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A new study from the CDC is the first to examine expected increases in Alzheimer's disease and related dementias in older Americans by racial and ethnic group.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
This article originally appeared on Kaiser Health News (KHN), a nonprofit news service covering health issues. It is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news
Authors: Yee A, Tsui NB, Chang YN, Au CS, Fok M, Lau LT, Chung T, Chung G, Kwan RY, Leung AY, Lau JY, Dai DL Abstract With the ageing of the global population, China is projected to be impacted significantly by the rising number of patients with Alzheimer's disease (AD). A cure for AD is not yet available, so society should be prepared for an increasing AD-related burden. In this review, we examine this impending problem and provide overviews on (a) the magnitude of the problem of AD in Hong Kong/China in the near future; (b) the genetic and lifestyle risk factors that contribute to AD; (c) current diagnostic appro...
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ00117K, PaperS ílvia Chaves, Asha Hiremathad, Daniel Tomás, Rangappa S. Keri, Luca Piemontese, M. Amélia Santos Donepezil and tacrine hybrids, containing a 2-hydroxyphenyl-benzimidazole chelating moiety and with multifunctional anti-AD activity, are evaluated in terms of metal (Cu and Zn) chelating capacity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
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