UPMC to build $200M immunology center in Pittsburgh

UPMC and the University of Pittsburgh announced Tuesday a new center for immunology, cancer treatment and aging that will be the vanguard of a new bio-innovation center. The $200 million UPMC Immune Transplant and Therapy Center will be part of a redesigned eight-story, 200,000-square-foot building located at 5000 Baum, a former Ford car plant and showroom. It will focus on the immune system, bringing together research from the university and UPMC that is geared t oward use at the clinical level…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news

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Warning for blood cancer patients who have undergone donor stem cell transplant
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Journal, Source Type: news
Conditions:   Benign Neoplasm;   Bone Marrow Transplantation Recipient;   Hematopoietic Cell Transplantation Recipient;   Malignant Neoplasm Interventions:   Procedure: Bone Marrow Transplantation;   Device: CliniMACS CD34 Reagent System;   Procedure: Peripheral Blood Stem Cell Transplantation Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
MONDAY, Aug. 13, 2018 -- The U.S. Food and Drug Administration is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin, as long-term use of the antibiotic has been associated...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Incidence and risk factors of secondary cancers after allogeneic stem cell transplantation: analysis of a single centre cohort with a long follow-up, Published online: 13 August 2018; doi:10.1038/s41409-018-0290-6Incidence and risk factors of secondary cancers after allogeneic stem cell transplantation: analysis of a single centre cohort with a long follow-up
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
High-dose chemotherapy and autologous stem cell transplantation in enteropathy-associated and other aggressive T-cell lymphomas: a UK NCRI/Cancer Research UK Phase II Study, Published online: 13 August 2018; doi:10.1038/s41409-018-0294-2High-dose chemotherapy and autologous stem cell transplantation in enteropathy-associated and other aggressive T-cell lymphomas: a UK NCRI/Cancer Research UK Phase II Study
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conditions:   Benign Neoplasm;   Bone Marrow Transplantation Recipient;   Hematopoietic Cell Transplantation Recipient;   Malignant Neoplasm Interventions:   Procedure: Bone Marrow Transplantation;   Device: CliniMACS CD34 Reagent System;   Procedure: Peripheral Blood Stem Cell Transplantation Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 9 August 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Katrine Togsverd-Bo, Peter Alshede Philipsen, Merete Haedersdal, Hans Christian WulfAbstractBackgroundSkin autofluorescence and pigmentation can estimate photodamage and sun exposure. These techniques may quantify differences in actinic damage between high-risk organ transplant recipients (OTRs) and immunocompetent patients.MethodsAge and gender-matched OTRs (n = 15) and immunocompetent controls (n = 15) with a new keratinocyte carcinoma (KC) were included. We measured skin autofluorescence (370...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
AbstractPurposeOvarian tissue (OT) cryopreservation is a treatment option for fertility preservation among young cancer patients. However, the procedure may involve a reduction in the GDF9- β expression and a delay in follicular growth after thawing and transplantation. The aim of this study was to evaluate whether supplementation of GDF9-β can compensate the reduction of this factor during the cryopresevation process and promote folliculogenesis after transplantation of thawed sheep ovarian tissue.MethodsSheep OT was cryopreserved using two methods of vitrification and slow freezing. Fresh and thawed OTs were th...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Although the incidence of cancer diagnoses in children has remained constant over the last few decades, survival has increased to a 5-year survival rate of 83% in 2003-2009.1 One of the main reasons for this improvement is major advances in treatment that were implemented during this period.2,3 One such advance is the use of hematopoietic cell transplantation (HCT), which has been shown to be effective for several high risk and relapsed hematological malignancies. Over 80% of those who survive the first 2 years of HCT treatment are expected to be long-term survivors.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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