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UPMC to build $200M immunology center in Pittsburgh

UPMC and the University of Pittsburgh announced Tuesday a new center for immunology, cancer treatment and aging that will be the vanguard of a new bio-innovation center. The $200 million UPMC Immune Transplant and Therapy Center will be part of a redesigned eight-story, 200,000-square-foot building located at 5000 Baum, a former Ford car plant and showroom. It will focus on the immune system, bringing together research from the university and UPMC that is geared t oward use at the clinical level…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news

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This case series describes 90-day mortality of patients who required tracheal, bronchial, or carinal reconstruction using stented aortic allografts supported by muscle flaps for treatment of inoperable airway disease including lung cancer, tracheal stenosis, or tracheomalacia.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Authors: Yang L, Zhang X, Lv X, Yu H Abstract Radiotherapy and surgery are important radical treatment options for cervical cancer, but the presence of a pelvic kidney complicates the situation. Fine radiation technique can help avoiding side effects. Radiation to the modified pelvis using intensity modulated radiotherapy (IMRT) followed by brachytherapy, while avoiding the renal allograft is technically feasible which ensures adequate target volume and reduces side effects. Here, the authors report a 45-year-old patient with invasive cervical cancer with a pelvic kidney who was treated by pelvic IMRT in combinatio...
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
CONCLUSION: Therapeutic strategies based on better molecular characterization of various histological types are certain to be used in the future. PMID: 29769011 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
This study showed that serially transplanted PDXs may not necessarily mirror the donor patients' diseases, and consequently, proper use of serially transplanted PDX models in translational cancer research requires careful molecular monitoring of the models. PMID: 29765518 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Fabbian F, De Giorgi A, Tiseo R, Cappadona R, Zucchi B, Rubbini M, Signani F, Storari A, De Giorgio R, La Manna G, Manfredini R Abstract OBJECTIVE: The aim of this retrospective study was to investigate the relationship between cancer, non-immunologic comorbidity, estimated by International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codification, gender and in-hospital mortality (IHM) in a large sample of renal transplant recipients (RTRs) living in the region Emilia-Romagna (RER) of Italy. PATIENTS AND METHODS: We evaluated IHM in RTRs admitted between 2000 and 2013 rec...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Recurrence risk was greater in sarcopenic patients, and greater alpha-fetoprotein and microvascular invasion were independent risk factors.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Liver, Gallbladder, and Biliary Tract Cancers News Source Type: news
A decades-long study found a decrease in cancer risk after liver transplantation. What factors may have contributed to the decline?American Journal of Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news
(Northwestern University) Scientists have developed a new compound that inhibits the spread of cancer cells, which is what makes the disease so lethal. The compound, metarrestin, significantly reduced metastasis by human prostate, pancreatic and breast cancer transplanted into mice. Mice treated with it had fewer metastatic tumors and lived longer than mice that did not receive treatment. Metarrestin is being submitted to the FDA as an investigational drug.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
CONCLUSIONS:  These data demonstrate safety and a potential role for aDLI in contributing to immune reconstitution and expanding tolerogenic regulatory T-cells in vivo after CD34-selected myeloablative haploidentical HSCT. PMID: 29769208 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
I was talking with someone recently about grief when she said that it felt like being on a roller coaster ride. This person is facing the impending death of a loved one even as there is no definitive timeline per the treatment team. We spoke of the dynamic of anticipatory grief and the ways in which it impacts the process of letting go of this person as she plans her future in the face of his eventual absence. I have found both in my therapeutic practice and in my personal life, that anticipatory grief genuinely effects mourners, although a 2006 article published in the Counseling, Psychology, and Health Journal quest...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Family Grief and Loss Health-related Interview Peer Support Personal anticipatory grief Cancer grieving Mourning widow widower Source Type: blogs
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