UPMC to build $200M immunology center in Pittsburgh

UPMC and the University of Pittsburgh announced Tuesday a new center for immunology, cancer treatment and aging that will be the vanguard of a new bio-innovation center. The $200 million UPMC Immune Transplant and Therapy Center will be part of a redesigned eight-story, 200,000-square-foot building located at 5000 Baum, a former Ford car plant and showroom. It will focus on the immune system, bringing together research from the university and UPMC that is geared t oward use at the clinical level…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news

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Harry Page, from New Jersey, US, had acute myeloid leukaemia when he was 19 years old and survived thanks to a bone marrow transplant from his brother, Ryan, who then died in 2006.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The thymus atrophies with age, and since its primary function is to support the maturation of T cells, this means that the supply of new T cells, fresh and ready for action, also declines with age. This contributes greatly to immunosenescence, the progressive age-related failure of the immune system to respond to pathogens and destroy damaged or malfunctioning cells. Numerous research groups are attempting to restore the thymus to youthful size and activity, and thus also restore the supply of T cells, and reverse loss of immune function. A wide variety of approaches are under development, from gene therapies and small mol...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
AbstractObjectiveTo investigate prognostic factors of  more than 10 years of survival for liver cancer patients after liver transplantation.MethodsFrom May 2000 to May 2007, a total of 134 liver cancer patients who underwent liver transplantation in the Department of Hepatobiliary Surgery, Peking University People ’s Hospital, were continuously and retrospectively enrolled. The patients included 120 males and 14 females. There were 124 cases (92.5%) of primary hepatocellular carcinoma, 9 cases (6.7%) of cholangiocarcinoma, and 1 case of mixed hepatocellular carcinoma and cholangiocarcinoma. Patients with ...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Adults with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis, especially in patients who relapsed within 6 months of complete remission 1 (CR1). Allogeneic hematopoietic stem cell transplantat...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
In conclusion, our findings provide a novel biological basis to support the current successful strategy using combined VEGF/PD ‐1 signalling blockade in cancer therapy.
Source: Journal of Cellular and Molecular Medicine - Category: Molecular Biology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractPurpose of ReviewThis review discusses the pathophysiology, risk factors, and the advances in the prevention or treatment of graft-vs-host disease (GvHD) by exploiting adjunct virotherapy. In addition, nonviral adjunct therapeutic options for the prevention of GvHD in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are discussed. The role of oncolytic viruses to treat different HSCT-eligible hematological cancers is also considered and correlated with the issue of GvHD in the context of allo-HSCT.Recent FindingsEmerging therapies focused on the prevention or treatment of GvHD include t...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
Conclusion: Treatment strategies for elderly patients (≥65 years) with single HCC ≤5 cm should emphasize SR as the primary therapy, while RFA can be an alternative to SR for those>75 years with single HCC ≤3 cm.
Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
ConclusionHypothyroidism is associated with poorer overall and recurrence ‐free survival of HCC patients receiving liver transplantation. These results require validation.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionThis case highlights the complexities of care of patients with coexistent cancers, demonstrates rapid progression of primary cutaneous ALCL on nivolumab and introduces a novel adverse effect of Talimogene laherparepvec.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
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