Lipofilling as a Treatment for Vestibulodynia

Condition:   Vestibulodynia Interventions:   Procedure: Adipose derived stem cell transplantation via lipofilling;   Procedure: Surgical excision Sponsor:   University Hospital, Ghent Recruiting
Source: - Category: Research Source Type: clinical trials

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Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader, Eva Herrmann, Ulrike Koehl
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Controlling graft-versus-host disease (GVHD) remains a major unmet need in stem cell transplantation, and new, targeted therapies are being actively developed. CD28-CD80/86 costimulation blockade represents a promising strategy, but targeting CD80/CD86 with CTLA4-Ig may be associated with undesired blockade of coinhibitory pathways. In contrast, targeted blockade of CD28 exclusively inhibits T cell costimulation and may more potently prevent GVHD. Here, we investigated FR104, an antagonistic CD28-specific pegylated-Fab′, in the nonhuman primate (NHP) GVHD model and completed a multiparameter interrogation comparing i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Warning for blood cancer patients who have undergone donor stem cell transplant
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Journal, Source Type: news
Conditions:   Benign Neoplasm;   Bone Marrow Transplantation Recipient;   Hematopoietic Cell Transplantation Recipient;   Malignant Neoplasm Interventions:   Procedure: Bone Marrow Transplantation;   Device: CliniMACS CD34 Reagent System;   Procedure: Peripheral Blood Stem Cell Transplantation Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI) Recruiting
Source: - Category: Research Source Type: clinical trials
The original version of this article contained a mistake in fig. 1a."Autologous HCT(n=111)" should be changed to"Allogeneic HCT (n=51)". Correct figure is presented below.
Source: Annals of Hematology - Category: Hematology Source Type: research
We report here on 22 APL patients treated with prolonged ATRA-ATO therapy at the time of disease relapse. Twenty patients obtained molecular complete remission (CRm) after 2 cycles (90%). Of these, two patients underwent hematopoietic stem cell transplant (HSCT) while the remaining proceeded to receive additional cycles (up to a total of 5) of ATRA-ATO. With a median follow-up of 58  months from the time of relapse (range: 21–128 months), the 4-year OS probability was 0.85 (95% CI 0.61–0.94), DFS was 0.74 (95% CI 0.49–0.88), and EFS 0.68 (95% CI 0.45–0.83). Two patients were resistant to A...
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractAutologous stem cell transplant (ASCT) is standard consolidation therapy in management of multiple myeloma (MM) patients. We reviewed records of all consecutive MM patients who underwent ASCT with high-dose melphalan at our center from year 2002 to 2016. A total of 141 ASCT were conducted (90 males and 51 females) with median age of 55  years (23–68 years). Median time from diagnosis to transplant was 7 months (3–79), with majority of patients underwent transplant in first remission, while 17 (12%) patients received transplant beyond first remission. Eighty-three percent patients obtained...
Source: Annals of Hematology - Category: Hematology Source Type: research
MONDAY, Aug. 13, 2018 -- The U.S. Food and Drug Administration is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin, as long-term use of the antibiotic has been associated...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionsThe underlying pathogenesis of new-onset seizures or epilepsy in recipients of transplantation needs to be further elucidated. In addition, more information is required from prospective studies and research focusing on therapeutic strategies.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 12 August 2018Source: Stem Cell ResearchAuthor(s): Huilin Li, Haiyun Pei, Jiqin Nie, Mingyi Qu, Zeng Fan, Yali Jia, Lijuan He, Xue Nan, Wen Yue, Xuetao PeiAbstractPrimary arterial endothelial cell (AEC) is an attractive source of tissue-engineered blood vessels for therapeutic transplantation in vascular disease. However, scarcity of donor tissue, inability of proliferation and undergo de-differentiation in culture remain major obstacles. We derived a stable induced pluripotent stem cell (iPSC) line possessed all the characteristics of pluripotent state from human umbilical arterial endot...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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