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Can treatments for arthritis be repurposed for dementia? – Alzheimer’s Society comments

New research suggests that drugs used to treat rheumatoid arthritis could reduce the risk of patients developing dementia.
Source: Alzheimers Society - Category: Geriatrics Source Type: news

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In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Chronic lack of sleep makes it hard to focus on a task. As if this didn’t make complete logical sense, multiple research studies have shown that sleep deprivation has about the same effect on our cognition and coordination as a few alcoholic beverages. What do you do when you need to concentrate, but you’re tired? Many of us reach for a cup of coffee, or a soda. Mountains of solid research have shown us that caffeine (in doses ranging between 30 and 300 milligrams) improves attention, alertness, reaction time, and mood, especially when we’re tired. An average cup of brewed coffee contains between 80 and 1...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Exercise and Fitness Source Type: blogs
Objective To determine whether hospital admission for autoimmune disease is associated with an elevated risk of future admission for dementia. Methods Retrospective, record-linkage cohort study using national hospital care and mortality administrative data, 1999–2012. Cohorts of people admitted to hospital with a range of autoimmune diseases were constructed, along with a control cohort, and followed forward in time to see if they developed dementia. 1 833 827 people were admitted to hospital with an autoimmune disease; the number of people in cohorts for each autoimmune disease ranged from 1019 people in ...
Source: Journal of Epidemiology and Community Health - Category: Epidemiology Authors: Tags: Press releases Research reports Source Type: research
It’s MS Awareness Week in the United States — the time of year that the National Multiple Sclerosis Society and people living with MS try to spread awareness of this disease. For the past several years, I’ve determined to spend this week educating people who live with MS about the disease they have. For past MS awareness weeks, I’ve written pieces on MS history and about the first recorded cases of MS. Today I write about research suggesting what might be in some of our futures. It’s not a happy topic, but I believe that forewarned is forearmed. A recent study pub...
Source: Life with MS - Category: Neurology Authors: Tags: multiple sclerosis awareness life with MS Living with MS MS and family MS symptoms trevis gleason Source Type: blogs
A new study linking autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, and later dementia strengthens the hypothesis that Alzheimer's may have an autoimmune component, researchers say.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Dear Carol: Last year Christmas was a mess and I’m determined to make this year better. Dad had a stroke two years ago and uses a wheelchair and mom has rheumatoid arthritis and uses a walker, so they both need a place with easy access. That would be my house. Both of my brothers, their wives, and their children join us. Along with our kids, the total of children is five. They are good kids but noisy which bothers my dad. Also, my brothers have opposing political views so I’m praying they don’t get into politics. To make things even more complicated, Mom is super judgmental and finds something to com...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Conclusion: Despite the significant burden mental disorders impose on society, investment and pharmaceutical innovation in this disease area remains comparatively low. Policymakers should consider new strategies to stimulate public and private investment in the research and development of novel and effective therapies to treat schizophrenia and other mental disorders. Introduction Over the last two decades, there have been remarkable breakthroughs in healthcare. These breakthroughs include the development of novel pharmaceutical treatments that have significantly improved outcomes for patients suffering from various medica...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Bipolar Disorder Current Issue Drug Development Mental Disorders Mood Disorders Original Research Psychiatry Psychopharmacology disease burden expenditures major depressive disorder pharmaceutical innovation research and developmen Source Type: research
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
Objective: We investigated whether a subset of genes involved with increased risk of inflammation are also associated with increased risk for Alzheimer’s disease (AD). Background: Late-onset AD, the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggest a relationship between inflammation and AD, it is unclear whether genes associated with inflammation are also involved with Alzheimer’s pathogenesis. Methods: Using summary statistics (p-values and odds ratios) from genome-wide association studies of over 100,000 individuals, we systema...
Source: Neurology - Category: Neurology Authors: Tags: Aging and Dementia: Genetics Source Type: research
More News: Alzheimer's | Arthritis | Dementia | Geriatrics | Rheumatoid Arthritis | Rheumatology