The optimal timing of adipose derived stem cells injection to improve skin flap survival in a rat model

ConclusionsWe demonstrate that the skin flap viability can be enhanced by local ASC administration simultaneously with flap elevation or 2  days prior to flap elevation. Their beneficial effect is attributed to paracrine secretion VEGF which enhanced the skin flap vascularity. The angiogenic effect of ASCs can be maximized when the ASCs are injected at the time of flap elevation.Level of Evidence: Not ratable

Source: European Journal of Plastic Surgery - February 13, 2018 Category: Cosmetic Surgery Source Type: research