Most commonly prescribed drug for infantile epilepsy may also be most effective

(Weill Cornell Medicine) Levetiracetam, the most commonly prescribed drug for US infants with epilepsy, may be significantly more effective than the second-choice drug phenobarbital, according to a new study by scientists from Weill Cornell Medicine, NewYork-Presbyterian and 16 other research institutions. The findings provide the first evidence to favor levetiracetam in infants.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). The anticonvulsant efficac...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Charlotte Figi, a child with a catastrophic type of epilepsy who went on to inspire a CBD movement, has passed away at age 13. CNN's Dr. Sanjay Gupta reflects on her life.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): María Puig-Molto, Emilio Pol-Yanguas, Lidia Segarra, Blanca Lumbreras
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Li R, He M, Wu B, Zhang P, Zhang Q, Chen Y Abstract α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-m...
Source: Brazilian Journal of Medical and Biological Research - Category: Research Tags: Braz J Med Biol Res Source Type: research
Publication date: Available online 8 April 2020Source: Psychiatric Clinics of North AmericaAuthor(s): Benjamin Tolchin, Lawrence J. Hirsch, William Curt LaFrance
Source: Psychiatric Clinics of North America - Category: Psychiatry Source Type: research
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): Andreu Massot-Tarrús, Kevin P. White, Seyed Reza Mousavi, Susan Hayman-Abello, Brent Hayman-Abello, Seyed M. Mirsattari
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253879 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
In this report, we present a 5-year-old boy who had dysmorphic features, hypotonia, developmental and mental delay, epileptic spasms, recurrent apnea and respiratory failure that led to the diagnosis of an unreported mutation of a rare form of CDG-Ix. This mutation in the STT3B gene affects the catalytic subunit of the oligosaccharyltransferase and the recipient substrate properties, which in part have the same functions in N-glycosylation. A novel homozygous mutation in the STT3B presence of c.38C> G that encodes p.S13W (p.Ser13Trp) was detected with next generation sequencing. The CDG clinical spectrum can be unusual,...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253874 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
A Colorado girl with a rare form of epilepsy whose recovery inspired the name of a medical marijuana oil that drew families to the state has died
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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