A Case of Mast Cell Leukemia: A Review of the Pathophysiology of Systemic Mastocytosis and Associated Psychiatric Symptoms

Mast cells, a type of white blood cell, are activated by allergens and stimulate the immune system. Once activated, these cells release immune mediators in a process called degranulation. These immune mediators include tryptase, histamine, serotonin, and cytokines and are responsible for producing inflammation. Mast cells are found throughout the body, including in the brain, especially around blood vessels and nerve endings. Mast cell degranulation is responsible for common allergic responses including eczema and anaphylaxis.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Source Type: research