DJ-1 is a useful biomarker for invasive extrahepatic cholangiocarcinoma

We have previously reported that DJ-1 protein is up-regulated in cholangiocarcinoma compared with non-neoplastic epithelium of the bile duct in a study using liquid chromatography mass spectrometry-based proteomics. The aim of this study was to clarify whether DJ-1 expression offers a biomarker for patients with invasive extrahepatic cholangiocarcinoma (EHCC) who undergo surgical resection with curative intent. Positive immunohistochemical (IHC) staining of DJ-1 was significantly more frequent in the cytoplasm of 96 invasive EHCCs (n=28, 29.2%) than in that of 66 non-neoplastic epithelial lesions adjacent to invasive EHCC (n=7, 10.6%; P=.006).

Source: Human Pathology - February 12, 2018 Category: Pathology Authors: Yukiko Tabata, Yoshitsugu Nakanishi, Kanako C. Hatanaka, Yutaka Hatanaka, Takahiro Tsuchikawa, Keisuke Okamura, Takehiro Noji, Toshiaki Shichinohe, Yoshihiro Matsuno, Satoshi Hirano Source Type: research