Demystifying Medicine: Amyotrophic Lateral Sclerosis (Lou Gehrig ’s Disease): Are We Making Progress? with Bryan Traynor MD, PhD, MMSc, NIA and Mary Kay Floeter, MD, PhD, NINDS

Date: Tuesday, 03 27, 2018; Speaker: Bryan Traynor MD, PhD, MMSc, NIA; Mary Kay Floeter, MD, PhD, NINDS; Building: Building 50; 1227; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events

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Condition:   Amyotrophic Lateral Sclerosis Intervention:   Drug: Riluzole Oral Soluble film (ROSF) 50 mg Sponsors:   Aquestive Therapeutics;   inVentiv Health Clinical;   Covance Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we aimed to compare the immunomodulatory properties of MSCs isolated from the bone marrow of patients suffering from ALS and healthy donors. Moreover, the influence of proinflammatory cytokines on the immunoregulatory functions of MSCs was also evaluated. We found that MSCs from ALS patients and healthy donors comparably affected mitogen-stimulated peripheral blood mononuclear cells and reduced the percentage of T helper (Th)1, Th17 and CD8+CD25+ lymphocytes. These MSCs also equally increased the percentage of Th2 and CD4+FOXP3+ T lymphocytes. On the other hand, MSCs from ALS patients decreased more strongly...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractNeuromuscular disorder is a muscular and nervous disorder resulting in muscular weakness and progressively damages nervous control, such as amyotrophic lateral sclerosis (ALS) and myopathy (MYO). Its diagnosis can be possible by classification of ALS, MYO, and normal electromyogram (EMG) signals. In this paper, an effective method based on variational mode decomposition (VMD) is proposed for identification of neuromuscular disorder of EMG signals. VMD is an adaptive signal decomposition which decomposes EMG signals nonrecursively into band-limited functions or modes. These modes are used for extraction of spectral ...
Source: Health Information Science and Systems - Category: Information Technology Source Type: research
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Miguel Leal Rato, Gonçalo S Duarte, Tiago Mestre, Mamede de Carvalho, Joaquim J Ferreira
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 September 2018Source: Pharmacological ResearchAuthor(s): Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong ZhouAbstractIn amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93 A/cpYFP) tha...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
International Journal of Clinical Practice, EarlyView.
Source: International Journal of Clinical Practice - Category: Internal Medicine Authors: Source Type: research
Conclusions Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression.
Source: Journal of Speech, Language, and Hearing Research - Category: Speech-Language Pathology Source Type: research
Muscle&Nerve,Volume 0, Issue ja, -Not available-.
Source: Muscle and Nerve - Category: Internal Medicine Authors: Source Type: research
Our objective was to quantify health service utilisation including monitoring and treatment of respiratory complications for adults with neuromuscular disease (NMD), identifying practice variation and adherence to guideline recommendations at a population level. We conducted a population-based longitudinal cohort study (2003–2015) of adults with NMD using hospital diagnostic and health insurance billing codes within administrative health databases. We identified 185 586 adults with NMD. Mean age 52 years, 59% female. 41 173 (22%) went to an emergency department for respiratory complications on average 1.6 times ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory clinical practice Original Articles: Neuromuscular disease Source Type: research
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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