IL-13 acidifies airway surface liquid pH via an omeprazole inhibitable mechanism
In this study, we evaluated if IL-13 acidifies ASL pH and whether omeprazole modulates this response in vitro. Furthermore, we identified whether ASL pH is altered in chronic rhinosinusitis with nasal polyps (CRSwNP) and whether it is associated with type-2 cytokines in nasal tissue in vivo.
Authors: Ring B, Burbank AJ, Mills K, Ivins S, Dieffenderfer J, Hernandez ML Abstract Objectives: Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC) in adolescents with asthma.Methods: Two hundred forty pulmonary function measu...
Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Fazlurrahman Khan, Dung Thuy Nguyen Pham, Sandra Folarin Oloketuyi, Panchanathan Manivasagan, Junghwan Oh, Young-Mog KimAbstractBiofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit ...
WINTER is the hardest time of year for cystic fibrosis sufferers, a charity has revealed.
Thought it would be interesting to see how the competitiveness of each field has changed. Percent of applicants who matched to the specialty, listed in order of descending competitiveness: 1. Gastroenterology - 62.8% 2. Pulmonology/Critical Care - 69.5% 3. Rheumatology - 71.3% 4. Cardiovascular Disease - 72.8% 5. Hematology and Oncology - 77.4% 6. Allergy and Immunology - 83.9% 7. Endocrinology - 87.1% 8. Hospice and Palliative Medicine - 87.2% 9. Geriatrics (Internal Medicine) - 90.7% 10... IM subspecialty competitiveness
Conclusions: Variation in the NAT1 gene modifies asthma risk in children exposed to secondhand-smoke. To our knowledge, this is the first report of a gene-environment interaction between NAT1 variants, smoke exposure, cotinine levels, and pediatric asthma. NAT1 genotype may have clinical utility as a biomarker of increased asthma risk in children exposed to smoke. PMID: 31809667 [PubMed - as supplied by publisher]
CONCLUSION: Our results did not show that S. aureus found in nasal mucosa membrane is significantly different in patients with or without NP. However, association of the presence of S. aureus in patients with nasal polyposis with asthma, allergy and inflammation has been shown. PMID: 31785225 [PubMed - as supplied by publisher]
Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids. Recidivism of polyps is common, and patients require long-term follow-up.
Abstract Remodeling refers to the development of specific but potentially irreversible structural changes in tissue. Caucasian eosinophilic chronic rhinosinusitis (CRS) with polyps associated or not with cystic fibrosis was discriminated by edema from CRS without nasal polyps, characterized by extensive fibrotic fields. However, changes in epithelial and extracellular matrix structures are common findings in all types of chronic inflammatory diseases of upper airways, but rarely specific and highly variable in extend. Recent studies have shown that remodeling in CRS appears to occur in parallel, rather than purel...