IL-13 acidifies airway surface liquid pH via an omeprazole inhibitable mechanism

In this study, we evaluated if IL-13 acidifies ASL pH and whether omeprazole modulates this response in vitro. Furthermore, we identified whether ASL pH is altered in chronic rhinosinusitis with nasal polyps (CRSwNP) and whether it is associated with type-2 cytokines in nasal tissue in vivo.

Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Jin Young Min, Julia He Huang, James E. Norton, Lydia A. Suh, Caroline P.E. Price, Roderick G. Carter, Su Y. Jung, Hyung S. Kim, David B. Conley, Stephanie Shintani-Smith, Kevin C. Welch, Anju T. Peters, Leslie C. Grammer, Whitney W. Stevens, Kathryn E. H Source Type: research