Adenosine Metabolism, Immunity and Joint Health.

Adenosine Metabolism, Immunity and Joint Health. Biochem Pharmacol. 2018 Feb 07;: Authors: Hasko G, Antonioli L, Cronstein BN Abstract The purine nucleoside adenosine is a present in most body fluids where it regulates a wide variety of physiologic and pharmacologic processes. Adenosine mediates its effects through activating 4 G protein-coupled receptors expressed on the cell membrane: A1, A2A, A2B, and A3. The adenosine receptors are widely distributed in the body, and tissues with high expression include immune tissues, cartilage, bone, heart, and brain. Here we review the source and metabolism of adenosine and the role of adenosine in regulating immunity and cartilage biology. PMID: 29427624 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29427624?dopt=Abstract

Source: Biochemical Pharmacology - February 7, 2018 Category: Drugs & Pharmacology Authors: Hasko G, Antonioli L, Cronstein BN Tags: Biochem Pharmacol Source Type: research