The Fusobacterium story as of 2018 – a very long post

This study followed a previous study that suggested an incidence of 1 per million.  However, in this study they estimated 14.4 per million in the 15-30 age group.  This rare disease now did not seem quite so rare. This information caused me to think about the risk to adolescents and young adults from Fusobacterium pharyngitis.  Much thought led to this perspective published in the Annals of Internal Medicine: Expand the Pharyngitis Paradigm for Adolescents and Young Adults Robert M. Centor, MD Current guidelines and review articles emphasize that clinicians should consider group A !-hemolytic streptococcus in the diagnosis and management of patients with acute pharyngitis. Recent data suggest that in adolescents and young adults (persons aged 15 to 24 years), Fusobacterium necrophorum causes endemic pharyngitis at a rate similar to that of group A !-hemolytic streptococcus. On the basis of published epidemiologic data, F. necrophorum is estimated to cause the Lemierre syndrome—a life-threatening suppurative complication—at a higher incidence than that at which group A streptococcus causes acute rheumatic fever. Moreover, these estimates suggest greater morbidity and mortality from the Lemierre syndrome. The diagnostic paradigm for adolescent pharyngitis should therefore be expanded to consider F. necrophorum in addition to group A streptococcus. Expanding the pharyngitis paradigm will have several important implications. Further epidemiologic r...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs

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Publication date: Available online 16 November 2019Source: Food ChemistryAuthor(s): Wenjun Zhao, Qing Shu, Guoqing He, Chen QiheAbstractThis work investigated the reduction of bovine whey proteins antigenicity by ultrasonic pretreatment and microbial fermentation. Firstly, bovine whey proteins was pretreated by ultrasonic techniques, and its secondary structure was detected by circular dichroism. The pretreated whey proteins was used as the fermentation substrate by Kluyveromyces marxianus for microbial transformation. The single factor design and Box-Behnken Design (BBD) were carried out with the aim to optimize culture t...
Source: Food Chemistry - Category: Food Science Source Type: research
Authors: Gatti M, Raschi E, De Ponti F Abstract BACKGROUND: The management of Klebsiella pneumoniae carbapenemase producing (KPC) infections represents a major challenge. Several safety and efficacy concerns are shared by available antibiotics used in KPC infections, leading to the occurrence of serious adverse drug reactions (ADRs), with ceftazidime-avibactam possibly showing a more favourable risk-benefit profile. We investigated the potential impact of resistance on ADR reports in countries with different prevalence of KPC isolates (Italy vs. United Kingdom [UK]), and described safety profile of newer and older ...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Publication date: 25 December 2019Source: Journal of Industrial and Engineering Chemistry, Volume 80Author(s): Seyed Hossein Mansourian, Shahrokh Shahhosseini, Ali MalekiAbstractThe possibility of using ultrasound irradiation to enhance a model fuel desulfurization process has been investigated in this work. For this reason, oxidative desulfurization (ODS) and ultrasound assisted oxidative desulfurization (UAOD) processes were applied, using oxygen, as the only oxidative agent, and polyoxometalate (POM) catalysts. The catalysts were analyzed using FT-IR, XRD, EDX, SEM and N2 adsorption–desorption isotherms along with...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Conclusion: Simulations demonstrate the feasibility of endobronchial ultrasound applicators to deliver thermal coagulation of 2-3 cm diameter tumors adjacent to or accessible from major and deep lung airways. PMID: 31726895 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Publication date: Available online 15 November 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Zhipan Wei, Bangtian Peng, Yulin Bai, Zaiqiang Wu, Yanwei Zhang, Feng Ai, Wanli GaoAbstractBoth cardiac myxomas and papillary fibroelastomas are primary benign cardiac tumors, but it is very rare for tumors with different histologies to occur in different valves of the same heart. A 5-month-old infant underwent resection of a mitral valve mass + mitral valvuloplasty at our hospital. The tricuspid valve mass was still small, and no tricuspid regurgitation was observed; therefore, the tricuspid valve mass ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
ConclusionOur study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations.Key Points•First study to assess ILD among predominantly Black RA patients.•The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease.•COPD was the most common airway disease among non-RA-ILD Black population.•GERD was found in approximately one-third of ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
We present a 48 year-old active duty physician who initially presented in 2007 with dyspnea and cough. Despite the absence of variable obstruction on spirometry, a clinical diagnosis of asthma was made. The patient's symptoms were temporized with inhaled corticosteroids and bronchodilators, titrated to his symptoms, until eventual therapeutic failure resulted in re-referral to pulmonary. Chest computed tomography (CT) showed ground-glass nodules and patchy airspace opacities with evidence of thoracic lymphadenopathy. A positron emission tomography CT (PET CT) showed diffuse adenopathy throughout his thorax and abdomen with...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: June 2020Source: Nonlinear Analysis: Real World Applications, Volume 53Author(s): Yu Yang, Lan Zou, Jinling Zhou, Cheng-Hsiung HsuAbstractThis paper is concerned with the dynamics of a waterborne pathogen model with spatial heterogeneity and general incidence rate. We first establish the well-posedness of this model. Then we clarify the relationship between the local basic reproduction number R̃ and the basic reproduction number R0. It could be seen that R0 plays an important role in determining the global dynamics of this model. In fact, we show that the disease-free equilibrium is globally asymptotical...
Source: Nonlinear Analysis: Real World Applications - Category: Research Source Type: research
This article will review the imaging features of common benign and malignant conditions of the female urethra including diverticula, benign cystic and solid lesions, malignancy, surgical slings, and injection of bulking agents.
Source: Abdominal Imaging - Category: Radiology Source Type: research
ConclusionFifteen years with a national database have resulted in a marked quality improvement: Denmark has 85% minimally invasive hysterectomies and has reduced the number of major complications by 50%.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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