Post-translational regulation of the maternal-to-zygotic transition.

Post-translational regulation of the maternal-to-zygotic transition.
Cell Mol Life Sci. 2018 Feb 09;:
Authors: Liu C, Ma Y, Shang Y, Huo R, Li W
Abstract
The maternal-to-zygotic transition (MZT) is essential for the developmental control handed from maternal products to newly synthesized zygotic genome in the earliest stages of embryogenesis, including maternal component (mRNAs and proteins) degradation and zygotic genome activation (ZGA). Various protein post-translational modifications have been identified during the MZT, such as phosphorylation, methylation and ubiquitination. Precise post-translational regulation mechanisms are essential for the timely transition of early embryonic development. In this review, we summarize recent progress regarding the molecular mechanisms underlying post-translational regulation of maternal component degradation and ZGA during the MZT and discuss some important issues in the field.
PMID: 29427077 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - February 9, 2018 Category: Cytology Authors: Liu C, Ma Y, Shang Y, Huo R, Li W Tags: Cell Mol Life Sci Source Type: research