Expression of MDM2 and p16 in Angiomyolipoma

Angiomyolipoma (AML) arises primarily from the kidney, but may grow into the retroperitoneal space mimicking a primary retroperitoneal tumor. Fine needle aspiration (FNA) and core needle biopsy (CNB) of AML, particularly the fat-predominant variant, may be difficult to distinguish from retroperitoneal well-differentiated liposarcoma (WDLS) or lipoma. Commonly used immunomarkers, MDM2 and p16, have proven useful in diagnosing WDLS and dedifferentiated liposarcoma (DDLS), while HMB45 and Melan-A are melanocyte-related markers characteristically expressed in AML.

Source: Human Pathology - February 10, 2018 Category: Pathology Authors: Xiaoqi Lin, William B. Laskin, Xinyan Lu, Yaxia Zhang Tags: Original contribution Source Type: research