Comparative evidence for the importance of the amygdala in regulating reward salience

Publication date: August 2018 Source:Current Opinion in Behavioral Sciences, Volume 22 Author(s): Christopher R Pryce Environmental stimuli and life events are often of emotional relevance to the individual. This is due to their recognition and processing by the brain's neural circuits for emotion. In terms of emotion valence, stimuli/events can be neutral (non-emotional), rewarding or aversive. In addition to its basic valence, the salience of an emotional stimulus, that is, how rewarding or how aversive it is, is also of critical importance. Quantitative changes in stimulus reward salience or aversion salience are likely to underlie some major symptoms in stress-related mental disorders. This includes low reward salience as the basis for diminished interest or pleasure in major depressive disorder (MDD) and for apathy (negative symptoms) in schizophrenia, and high aversion salience as the basis for depressed mood in MDD. Insight into the brain region(s) and cellular microcircuits wherein the saliences of reward and aversion stimuli are set is essential for understanding the neurobiology of emotion in health and mental disorders. Here I review the current evidence for the role of the amygdala in processing reward valence and salience, based on studies conducted in human, monkey and, in particular, rat and mouse. Human BOLD-fMRI studies demonstrate amygdala reactivity to reward and its reduction in MDD and schizophrenia. In monkey, some neurons in the basolateral amygdala ...
Source: Current Opinion in Behavioral Sciences - Category: Psychiatry & Psychology Source Type: research