Extracellular acidosis suppresses calcification of vascular smooth muscle cells by inhibiting calcium influx via L-type calcium channels.

In conclusion, acidosis significantly attenuated vascular calcification in association with downregulation of the LTCC/Ca2+/Runx2 pathway.
PMID: 29420074 [PubMed - as supplied by publisher]

Source: Clinical and Experimental Hypertension - February 8, 2018 Category: Cardiology Authors: Zhang S, Xu J, Feng Y, Zhang J, Cui L, Zhang H, Bai Y Tags: Clin Exp Hypertens Source Type: research